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| Synthesis and Biological Evaluation of 2-amino-3-phenylpropanoic Acid Derivatives Labeled With 18F |
| PENG Cheng1;MA Yun-chuan1;SU Yu-sheng1;HE Yong2;XU Jing-li2;CHEN Yu-rong2;QI Chuan-min2 |
| 1.PET Center of Xuanwu Hospital, Beijing 100053, China;2. Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing 100875, China |
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Abstract Methyl-2-(4-(2-fluoroethoxy) benzamido)-3-phenylpropanoate (MFBPA) and its hydrolysis product 2-(4-(2-fluoroethoxy)benzamido)-3-phenylpropanoic acid (FBPA) were synthesized and labeled by 18F. To evaluate applicability of 18F-MFBPA and 18F-FBPA in detecting malignant fibrosarcoma, some studies were carried on biodistribution, stabilities in vitro or in vivo and autoradiophotography. After 60 min of intravenous injection the accumulations of 18F-MFBPA and 18F-FBPA in tumor, muscle, blood and brain were 0.78±0.02, 0.72±0.04, 0.66±0.07, 0.38±0.03%ID/g and 0.95±0.05, 0.64±0.06, 0.65±0.04, 0.34±0.01%ID/g, respectively. Their ratios of tumor to muscle， tumor to blood, and tumor to brain were 1.18, 1.08, 2.05 and 1.46 1.48，2.79, respectively. The results indicated that 18F-FBPA might have more potential to be PET imaging agent.
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Received: 01 January 1900
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