Journal of Isotopes ›› 2018, Vol. 31 ›› Issue (5): 326-334.DOI: 10.7538/tws.2017.youxian.029

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The Progress of Nuclear Nanomedicines

ZHANG Huaming;LUO Shunzhong;WEI Hongyuan   

  1. Institute of Nuclear Physics and Chemistry, China Academy of engineering Physics, Mian yang 621999, China
  • Online:2018-10-20 Published:2020-08-14



  1. 中国工程物理研究院 核物理与化学研究所,四川  绵阳621999


This manuscript briefly summarized the progress in the last decade and predicted the development in the future of nano-radiopharmaceuticals. The major carrier materials for nanoparticle delivery are biomaterials such as liposomes, or biocompatible materials such as phosphates, hydroxyapatite. Currently, various radionuclides, such as 131I, 111In, 125I, 166Ho, 177Lu, 90Y, 225Ac are extensively used clinically or in research for diagnostic or therapeutic purpose. The preparation methodology of nano-radiopharmaceuticals includes post-irradiation activation, encapsulation, adsorption and etc. Many pre-clinical trials showed that nano-radiopharmaceuticals had displayed good specificity on cancer diagnosis and treatment, thus had became an important research direction in the diagnosis and treatment of cancer and personalized medical care.

Key words: radioactive nuclide, label, nano-technology, nanocarriers materials, nanomedicines



关键词: 放射性核素, 标记, 纳米技术, 纳米载体材料, 纳米药物