The Progress of Nuclear Nanomedicines

doi:10.7538/tws.2017.youxian.029

Abstract

Abstract:

This manuscript briefly summarized the progress in the last decade and predicted the development in the future of nano-radiopharmaceuticals. The major carrier materials for nanoparticle delivery are biomaterials such as liposomes, or biocompatible materials such as phosphates, hydroxyapatite. Currently, various radionuclides, such as ¹³¹I, ¹¹¹In, ¹²⁵I, ¹⁶⁶Ho, ¹⁷⁷Lu, ⁹⁰Y, ²²⁵Ac are extensively used clinically or in research for diagnostic or therapeutic purpose. The preparation methodology of nano-radiopharmaceuticals includes post-irradiation activation, encapsulation, adsorption and etc. Many pre-clinical trials showed that nano-radiopharmaceuticals had displayed good specificity on cancer diagnosis and treatment, thus had became an important research direction in the diagnosis and treatment of cancer and personalized medical care.

Key words: radioactive nuclide, label, nano-technology, nanocarriers materials, nanomedicines

摘要：

本文对近十年纳米核药的研究进展进行综述，展望其发展方向。纳米载体材料以生物材料如脂质体或生物友好材料如磷酸盐、羟基磷灰石等为主。根据诊断和治疗目的选择核素，如¹³¹I、¹¹¹In、¹²⁵I、¹⁶⁶Ho、¹⁷⁷Lu、⁹⁰Y、²²⁵Ac等。制备方法包括纳米粒子后辐照活化法、包覆法和吸附法等。大量预临床试验结果表明，纳米核药对肿瘤诊治具有较好的特异性，是肿瘤诊治和个性化医疗研究的重要方向。

关键词: 放射性核素, 标记, 纳米技术, 纳米载体材料, 纳米药物

ZHANG Huaming;LUO Shunzhong;WEI Hongyuan. The Progress of Nuclear Nanomedicines[J]. Journal of Isotopes, 2018, 31(5): 326-334.

张华明;罗顺忠;魏洪源. 纳米核药的研究进展[J]. 同位素, 2018, 31(5): 326-334.

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