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Optimization of the Radiosynthesis of the Dopamine Transporter Imaging Agent of 11C-β-CFT |
LI Haifeng1;XU Rengen1;LI Yungang2;CHEN Zhijun1;ZHANG Xiaojun2;ZHANG Jinming2 |
1.Depatment of Nuclear Medicine, Jiang Xi Cancer Hospital, Nanchang 330029, China;2.Depatment of Nuclear Medicine, Chinese PLA General Hospital, Beijing 100853, China |
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Abstract The optimization for high synthesis yield was designed with 11C-Triflate-CH3I as methylation agent for dopamine transporter imaging agent of 11C-β-CFT. The influence factors of the synthesis process were discussed, and the optimum synthetic conditions were established. In the paper, the study showed that the amount of precursor, the irradiation time, eluated condition, the reaction solvent etc could effect the synthetic efficiency. 11C-β-CFT was automatic synthesized on PET-CM-3H-IT-Ⅰ with the optimum process conditions as the irradiation time 10-24 minutes, 0.5-1.0 g/L of precursor in 0.2 mL acetone: acetonitrile(1∶1, V∶V) and room temperature. We obtained a radiochemical yield of (76.93±6.49)% (n=76, 11C-Triflate-CH3 EOB). The radiochemical purity of final products were over 97%. The specific activities of final products were over (56.26±1.55) TBq/g. It took 16 minutes from 11C-CO2 to 11C-β-CFT and the radio activity of 11C-β-CFT were (8.07±1.94) GBq (n=76). By optimization of the technological conditions, the target product was suitable for clinical, the synthetic process was reliable and full automated, the product yield was improved and the residual problem of Sep-Pak C18 was resloved.
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