JOURNAL OF ISOTOPES ›› 0, Vol. ›› Issue (): 0-0.DOI: 10.7538/tws.2016.youxian.068

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Samples Preparation of Breath Test 14C Tracer for Accelerator Mass Spectrometry

ZHANG Hui1,2;WANG Xiao-ming1;PANG Yi-jun1;ZHAO Qing-zhang1;CHEN Juan1;CHEN Bao-jun1;YANG Xian-lin1;HE Ming1;JIANG Shan1   

  1. 1.China Institute of Atomic Energy, Beijing 102413, China;2.Technical Physics Institute of Heilongjiang Academy of Sciences, Harbin 150086, China
  • Published:2017-01-09

基于加速器质谱测量的14C呼气试验样品制备方法研究

张慧1,2;王小明1;庞义俊1;赵庆章1;陈娟1;陈宝军1;杨宪林1;何明1;姜山1   

  1. 1.中国原子能科学研究院,北京102413; 2.黑龙江省科学院 技术物理研究所,黑龙江 哈尔滨150086

Abstract:

Carbon plays an important role in the metabolism of plants and human. Radiocarbon (14C) is an ideal tracer for vivo human metabolism, disease diagnosis and organ function assessment studies. In this paper, the preparation method of 14C breath test samples for accelerator mass spectrometry (AMS) measurement was developed in China. AMS, with its advantages of high sensitivity, small radioactivity dose, high precision, large measuring range, and long tracer cycle, can be used to measure cosmogenic nuclide 14C, which has long half-life. The current intensity of interested ion in ion source is an important parameter for the sensitivity of AMS measurement. The high beam current can improve the sensitivity of AMS. The preparation methods of breath test samples of 14C tracer were systematically studied to obtain high beam current using graphitization and carbonatization methods. A reliable preparation procedure of breath test samples for 14C tracer and its optimization parameters were determined by testing beam currents of various samples, which has laid a foundation for 14C-AMS technology at breath test tracer application.

Key words: accelerator mass spectrometry, breath test, radiocarbon, samples preparation, beam intensity

摘要:

采用加速器质谱法研究14C呼气试验样品的制备方法。采用长寿命放射性核素14C作为示踪核素,目前已广泛应用于生物代谢、疾病诊断和脏器功能评估。离子源引出的束流强度是衡量加速器质谱灵敏度的重要参数,为了获得较高的束流强度,本工作系统研究了14C呼气试验样品的石墨法、碳酸盐法两种制备方法,拟建立14C呼气试验样品制备流程,确定最高束流强度引出时的最优14C呼气试验样品制备参数,为14C呼气试验广泛应用提供实验基础。

关键词: 加速器质谱, 呼气试验, 14C, 样品制备, 束流强度