JOURNAL OF ISOTOPES

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Positron Emission Radiometals 64Cu, 68Ga, 86Y and 89Zr Labeled PET Drugs

CHEN Wen;WEI Hong-yuan;ZHOU Zhi-jun;LUO Shun-zhong   

  1. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900, China
  • Online:2017-02-20 Published:2017-03-06

金属正电子核素64Cu,68Ga,86Y和89Zr的PET标记药物研究进展

陈文;魏洪源;周志军;罗顺忠   

  1. 中国工程物理研究院 核物理与化学研究所,四川 绵阳621900

Abstract:

Positron emission radiometals 64Cu, 68Ga, 86Y and 89Zr have different half lives and special biological properties, not only enrich the diversity of PET drugs, but also provide a new opportunity for the diagnosis and treatment of disease. In recent years, positron emission radiometals 64Cu,  68Ga, 86Y and 89Zr have more and more applications in the medical diagnostics of PET (positron emission tomography). 64Cu has already had a significant impact in cancer hypoxia imaging. 68Ga is developing rapidly in the field of diagnosis of NET (Neuroendocrine tumor) tumor. 89Zr and 86Y are expected to play a role in the field of immunoPET and radioimmunotheray. This paper briefly reviews the research progress on the production and purification, solution coordination chemistry and applications of 68Ga, 86Y, 89Zr and 64Cu.

Key words: positron emission tomography, 64Cu, 68Ga, 86Y, 89Zr, coordination chemistry, clinical application

摘要:

64Cu,68Ga,86Y和89Zr具备不同的半衰期和特殊生物体内性质,丰富了PET药物的多样性,为疾病的诊断和治疗提供了新的契机。近年来,金属正电子核素64Cu,68Ga,86Y和89Zr标记的药物在正电子发射计算机断层显像(PET)诊断中的应用越来越多,64Cu在乏氧显像中发挥重要作用,68Ga在靶向神经内分泌(NET)类肿瘤的诊断药物领域发展迅速,86Y,89Zr有望在免疫PET和放射免疫治疗领域发挥作用。本文主要综述金属正电子核素64Cu,68Ga,86Y ,89Zr的生产与纯化,溶液配位化学以及应用方面的研究进展。

关键词: 正电子发射计算机断层显像(PET), 64Cu, 68Ga, 86Y, 89Zr, 配位化学, 临床应用