JOURNAL OF ISOTOPES

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Resonance Energy Transfer Molecular Imaging Application in Biomedicine

NIE Da-hong1,2;TANG Gang-hua1,3   

  1. 1.Guangdong Engineering Center for Translational Applications of Radiopharmaceuticals,The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China;2.Department of Radiotherapy, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China;3.Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China
  • Online:2016-11-20 Published:2016-11-21

共振能量转移分子显像在生物医学中的应用

聂大红1,2;唐刚华1,3   

  1. 1.中山大学附属第一医院 广东省医用放射性药物转化应用工程技术研究中心,广东 广州510080;2.中山大学附属第一医院 放疗科,广东 广州510080;3.中山大学附属第一医院 核医学科,广东 广州510080

Abstract:

Resonance energy transfer molecular imaging (RETI) can markedly improve signal intensity and tissue penetrating capacity of optical imaging, and have huge potential application in the deep-tissue optical imaging in vivo. Resonance energy transfer (RET) is an energy transition from the donor to an acceptor that is in close proximity, including non-radiative resonance energy transfer and radiative resonance energy transfer. RETI is an optical imaging technology that is based on RET. RETI mainly contains fluorescence resonance energy transfer imaging (FRETI), bioluminescence resonance energy transfer imaging (BRETI), chemiluminescence resonance energy transfer imaging (CRETI), and radiative resonance energy transfer imaging (RRETI). RETI is the hot field of molecular imaging research and has been widely used in the fields of biology and medicine. This review mainly focuses on RETI principle and application in biomedicine.

Key words: resonance energy transfer imaging, fluorescence resonance energy transfer, bioluminescence resonance energy transfer, chemiluminescence resonance energy transfer, radiative resonance energy transfer

摘要:

共振能量转移分子显像(RETI)能显著改善光信号强度和组织穿透性,可用于活体深度组织光学显像。共振能量转移(RET)是指发生在近距离的供体与受体之间的能量转移,包括非放射共振能量转移和放射共振能量转移。RETI是基于共振能量转移的光学成像技术,主要包括荧光共振能量转移显像(FRETI)、生物发光共振能量转移显像(BRETI)、化学发光共振能量转移显像(CRETI)和放射共振能量转移显像(RRETI)。目前,RETI是分子显像研究的热门领域,已用于生物医药学研究各领域。本文对RETI技术原理及其在生物医学中的应用进行综述。

关键词: 共振能量转移分子显像, 荧光共振能量转移, 生物发光共振能量转移, 化学发光共振能量转移, 放射共振能量转移