JOURNAL OF ISOTOPES

Previous Articles    

Development of 89Zr Labelled Radiopharmaceuticals

WANG Li-zhen;YANG Min   

  1. Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
  • Online:2016-05-20 Published:2016-06-03

89Zr标记放射性药物应用进展

王立振;杨敏   

  1. 江苏省原子医学研究所,卫生部核医学重点实验室,江苏省分子核医学重点实验室,江苏 无锡214063

Abstract:

Positron emission tomography (PET) is the most advanced molecular imaging technology with the advantage of high sensitivity and quantity analysis. Molecule probe is the key factor for PET. 89Zr is a novel imaging nuclide and suitable for labeling macromolecular bioactive substances such as antibody due to its favorably long half-life and energy. This review outlined the recent development of the production of 89Zr, labeling methods and application of 89Zr labelled radiopharmaceuticals.

Key words: 89Zr, PET, radiopharmaceuticals, labeling

摘要:

正电子发射计算机断层显像(PET)具有灵敏度高、可定量等优点,是当前发展迅速的分子显像技术。89Zr是一种新型正电子显像核素,半衰期及能量适中,适于大分子生物活性物质的标记及临床应用。本文对89Zr的生产、标记方法以及89Zr标记化合物的研究进展进行综述。

关键词: 锆-89, PET, 放射性药物, 标记