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Preparation and Biodistribution of 99mTc-Pamidronate as Bone Imaging Agent

LUO Hong-yi1;SHEN Lang-Tao2;LIANG Ji-xin1;YANG Chun-hui2;ZHANG Wen-Hui2;QIN Shao-peng1;WEI Cheng-jun1;LIU Hai-Chun3;WANG Jian-Hua3;LI Hong-yu2   

  1. 1.Department of Isotopes, China Institute of Atomic Energy, Beijing 102413, China;2.HTA CO., LTD., Beijing 102413, China;3.China Nuclear Industry Beijing 401 Hospital, Beijing 102413, China
  • Online:2016-02-20 Published:2016-03-01



  1. 1.中国原子能科学研究院 同位素研究所,北京102413;2.原子高科股份有限公司,北京102413;3.核工业401医院 核医学科, 北京102413


Labeling of Pamidronate (PAM) with 99mTc was studied by a direct labeling method in the presence of SnCl2•2H2O as reducing agent. The influences of the concentration of SnCl2•2H2O, PAM concentration and pH value, reaction time on labeling yield were investigated. The optimum labeling was determined. The results showed that the radiochemistry purity of 99mTc-PAM was more than 95%. Biodistribution studies in normal mice and rats showed very high uptake of 99mTc-PAM and long retain in bone. 99mTc-PAM was washed out from the blood very quickly. In addition, considerable uptake in the kidneys indicated this complex was excreted mainly by renal pathway. On the other hand, the radioactivity in liver, lung and heart was negligible. It could be known from SPECT images that 99mTc-PAM would be an excellent bone-imaging agent. Bone uptake of 99mTc-PAM was higher than that of 99mTc-MDP in mice. This study suggested that 99mTc-PAM was a promising bone imaging agent and further study was worthwhile.

Key words: bone imaging agent, 99mTc-PAM, biodistribution, SPECT imaging, 99mTc-MDP



关键词: 骨显像剂, 99mTc-帕米膦酸盐, 生物分布, SPECT显像, 99mTc-亚甲基二膦酸盐