Journal of Isotopes ›› 2017, Vol. 30 ›› Issue (3): 209-218.DOI: 10.7538/tws.2017.youxian.015

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Progress of Preparation and Applications of 68Ga-Labelled Radiopharmaceuticals

YANG Chun-hui1,3;LIANG Ji-xin1;SHEN Lang-tao1,2;LI Hong-yu1,2   

  1. 1.Department of Isotopes, China Institute of Atomic Energy, Beijing 102413, China;2.HTA CO., LTD., Beijing 102413, China;3.Department of Reactor Engineering Technology, China Institute of Atomic Energy, Beijing 102413, China
  • Online:2017-08-20 Published:2017-08-10



  1. 1.中国原子能科学研究院 同位素研究所,北京102413;2.原子高科股份有限公司,北京102413;3.中国原子能科学研究院 反应堆工程技术研究部,北京102413


Positron emission tomography (PET) has become the leading technology in the field of nuclear medicine. Currently, PET is widely used in tumor research, with high sensitivity, good resolution and so on. The construction of the 68Ge/ 68Ga generator has increased the application of 68Ga radiopharmaceuticals. The 68Ga radiopharmaceuticals are mainly applied on the imaging of oncological diseases, such as the targeting imaging of somatostatin receptor, human epidermal growth factor receptor, folate and so on. The potential for imaging of pulmonary and myocardial perfusion and ventilation as well as targeting imaging of inflammation, infection, have also been considered and fundamental exploration is ongoing. The application progress of 68Ga radiopharmaceuticals was reviewed, including production, receptors and derivatives, imaging of pre-clinical developments on diagnosis.

Key words: 68Ga, labeled, radiopharmaceuticals, PET imaging


正电子发射计算机断层显像(positron emission tomography, PET)为核医学领域的显像方法之一,广泛应用于肿瘤研究,灵敏度高,分辨率佳。近年来,68Ge/68Ga发生器的开发促进了68Ga标记的PET显像药物的研究和应用。68Ga放射性药物主要应用于肿瘤显像,如生长抑素受体、人表皮生长因子受体、叶酸等受体分子的靶向显像;也可用于心肌灌注、肺灌注和通气、炎症和感染显像等。本文主要介绍68Ga标记放射性药物相关的生产,标记涉及的受体及衍生物,以及显像研究等应用进展。

关键词: 68Ga, 标记, 放射性药物, PET显像