Journal of Isotopes ›› 2017, Vol. 30 ›› Issue (1): 36-42.DOI: 10.7538/tws.2017.30.01.0036

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The 18F-FDG-(OAc)4 Residual in 18F-FDG and its Bio-distribution in Mice

WANG Lei1;ZHANG Xiao-jun2;ZHOU Yan-li1;ZHANG Jin-ming2   

  1. 1.Department of Nuclear Medicine, Bao Tou central Hospital, baotou 014040, China;2.Department of Nuclear Medicine, The PLA General Hospital, Beijing 100853, China
  • Online:2017-02-20 Published:2017-03-06

18F-FDG-(OAc)418F-FDG中的残留及在小鼠体内的生物分布

王蕾1;张晓军2;周艳丽1;张锦明2   

Abstract:

To investigate the causes of 18F-FDG-(OAc)4 residual in 18F-FDG and the discrepancy of bio-distributions between 18F-FDG-(OAc)4 and 18F-FDG, 18F-FDG was prepared by hydrolysis on C-18 .The effect of NaOH dosage, elution rate, and eluent pH on 18F-FDG-(OAc)4 residual ,the metabolism and biodistribution profiles of 18F-FDG-(OAc)4 in mice were stutied. The results showed that insufficiency of NaOH was the main reason for 18F-FDG-(OAc)4 residual, while the elution rate and the pH of the eluent posed no impact. After injecting 18F-FDG-(OAc)4 60 minutes, the partially hydrolyzed product and 18F-FDG-(OAc)4 were found in metabolite of blood、urine and brain of the mice. The mice bio-distribution suggested that  the uptake of 18F-FDG-(OAc)4 and 18F-FDG by organs followed the same pattern apart from muscle.

Key words: 18F-FDG, 18F-FDG-(OAc)4, metabolism, bio-distribution

摘要:

为探讨18F-FDG-(OAc)418F-FDG中残留的原因及其与18F-FDG在生物体内代谢分布的异同,本研究利用固相柱水解法制备18F-FDG,研究NaOH用量、淋洗速率及淋洗液pH对18F-FDG-(OAc)4残留的影响,以及18F-FDG-(OAc)4在小鼠体内的代谢和分布规律。结果表明:NaOH不足是18F-FDG-(OAc)4残留的主要原因,淋洗速率和淋洗液pH对其残留没有影响;注射18F-FDG-(OAc)4 60 min后,小鼠血、尿和脑代谢物中发现18F-FDG-(OAc)4原形及部分水解物;小鼠体内分布结果显示,除肌肉外,18F-FDG-(OAc)418F-FDG在体内各脏器摄取值高低分布一致。

关键词: 氟-18-脱氧葡萄糖, 氟-18-四乙酰基脱氧葡萄糖, 代谢, 生物分布