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| Characterization of Methacetin-methoxy-13C |
| LU Wei-jing1;LU Hao1;YANG Wei-cheng1;GUAN Liang2;ZHU Cheng-mo2;LIU Wei-xia1;LI Shuai1;XU Zhong-jie1;CHEN Su-yun2;JIANG Lei2 |
| 1. Shanghai Research Institute of Chemical Industry, Shanghai 200062, China；2. Department of Nuclear Medicine, Ruijing Hospital, Shanghai Jiao Tong University, Shanghai 200025, China |
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Abstract Methacetin-methoxy-13C was synthesized by using methanol-13C with a novel method, and the characterization of it was performed using HPLC, LC-MS and 1HMNR. The results indicated that the synthetic was right. And the yield of methacetin-methoxy-13C was 70.0% with 99% 13C abundance and 99.8% purity. Compared with the classical method， there was more benefit. The methacetin 13C-breath test was performed with the synthetic on the live mice, which showed a precise reflection of alteration of liver function in liver injury and functional recovery.
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Received: 01 January 1900
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