177Lu-DOTMP在荷瘤小鼠体内的生物分布和兔SPECT显像研究

doi:10.7538/tws.2012.25.03.0160

同位素 ›› 2012, Vol. 25 ›› Issue (3): 160-164.DOI: 10.7538/tws.2012.25.03.0160

• 放射性药物和标记化合物 • 上一篇下一篇

¹⁷⁷Lu-DOTMP在荷瘤小鼠体内的生物分布和兔SPECT显像研究

邓新荣¹;向学琴¹;李凤林¹;樊彩云¹;刘子华¹;陈阳²;罗志福¹

1. 中国原子能科学研究院同位素研究所，北京102413;2. 中国原子能科学研究院核工业401医院核医学科,北京102413

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-09-24 发布日期:2012-09-24

The Research on Biodistribution of Bearing Sarcoma Mice and Rabbit SPECT Imaging of ¹⁷⁷Lu-DOTMP

DENG Xin-rong¹;XIANG Xue-qin¹;LI Feng-lin¹;FAN Cai-yun¹;LIU Zi-hua¹;CHEN Yang²;LUO Zhi-fu¹

1. Department of Isotope, China Institute of Atomic Energy, Beijing 102413, China；2. China Nuclear Industry Beijing 401 Hospital, China Institute of Atomic Energy, Beijing 102413, China

Received:1900-01-01 Revised:1900-01-01 Online:2012-09-24 Published:2012-09-24

摘要/Abstract

摘要： 以1,4,7,10-四氮杂环十二烷和亚磷酸为原料合成了1,4,7,10-四氮杂环十二烷-1,4,7,10-四甲撑膦酸（DOTMP），并对其进行了¹⁷⁷Lu标记；观察了¹⁷⁷Lu-DOTMP在骨转移癌模型鼠体内的生物分布，并对日本大耳白兔进行显像。荷瘤鼠体内的生物分布结果显示：¹⁷⁷Lu-DOTMP可以选择性地在骨组织吸收，具有良好的靶向性，而且在血中清除较快，在其它脏器只有少量的摄取。日本大耳兔显像结果显示：¹⁷⁷Lu-DOTMP主要聚集于膀胱组织，即¹⁷⁷Lu-DOTMP主要通过肾排泄；注射后22 h 骨骼放射性摄取明显，46 h骨骼中放射性积聚更多。以上结果表明，¹⁷⁷Lu-DOTMP具有良好的骨靶向性，值得进一步研究。

关键词: 1,4,7,10-四氮杂环十二烷-1,4,7,10-四甲撑膦酸(DOTMP), ¹⁷⁷Lu, 荷瘤小鼠, 生物分布, 日本大耳白兔, SPECT显像

Abstract: Cyclen(1,4,7,10-tetraazacyclododecane) and H₃PO₃ were used to synthesis DOTMP(1,4,7,10-tetraazacyclododecane-1,4,7,10-Tetraaminomethylenephosphonate)， and then DOTMP was labelled with ¹⁷⁷Lu.The research of biodistribution of ¹⁷⁷Lu-DOTMP in model mice bearing S180 sarcoma and SPECT imaging in Japanese white rabbit were also carried out. The results of biodistribution of bearing S180 mice indicated that ¹⁷⁷Lu-DOTMP cleared rapidly from blood and was selectively delivered to target bone. The radioactivity uptake was mainly in bone and less in other organs and tissues. The results of SPECT imaging of Japanese white rabbit showed that the radioactivity was accumulated in bladder. ¹⁷⁷Lu-DOTMP was mainly excreted by kidney. The uptake of the activity in the skeleton was observed significatantly within 22 h postinjection and it became quite significant at 46 h post-injection. It indicated that ¹⁷⁷Lu-DOTMP has good bone targeting and is worthy of further study.

Key words: DOTMP, ¹⁷⁷Lu, mice bearing S180 sarcoma cells, biodistribution, Japanese white rabbit, SPECT imaging

邓新荣 ;向学琴 ;李凤林 ;樊彩云 ;刘子华 ;陈阳 ;罗志福 . ¹⁷⁷Lu-DOTMP在荷瘤小鼠体内的生物分布和兔SPECT显像研究[J]. 同位素, 2012, 25(3): 160-164.

DENG Xin-rong;XIANG Xue-qin;LI Feng-lin;FAN Cai-yun;LIU Zi-hua;CHEN Yang;LUO Zhi-fu. The Research on Biodistribution of Bearing Sarcoma Mice and Rabbit SPECT Imaging of ¹⁷⁷Lu-DOTMP[J]. Journal of Isotopes, 2012, 25(3): 160-164.

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¹⁷⁷Lu-DOTMP在荷瘤小鼠体内的生物分布和兔SPECT显像研究

The Research on Biodistribution of Bearing Sarcoma Mice and Rabbit SPECT Imaging of ¹⁷⁷Lu-DOTMP

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