125I放射性粒子治疗癌症研究进展

doi:10.7538/tws.2019.youxian.009

摘要/Abstract

摘要：

恶性肿瘤目前的治疗方法主要包括手术、放疗、化疗等。近年来，放射性核素碘［¹²⁵I］粒子治疗肿瘤因其直接杀伤肿瘤病灶，在控制局部复发和转移方面具有一定优势。¹²⁵I半衰期较长（T_1/2=59.7 d），通过电子捕获释放低能γ射线（27 keV，特征X射线），适合用于近距离治疗肿瘤。¹²⁵I 粒子可采用手术植入的方式埋植在肿瘤组织，对治疗肺癌、胰腺癌和前列腺癌等实体恶性肿瘤疗效显著, 治疗操作简单、损伤小，有较广泛应用前景。本文对¹²⁵I放射性核素制备、¹²⁵I放射性粒子制备及其临床肿瘤治疗情况及展望进行了综述。

关键词: ¹²⁵I放射性粒子, 介入治疗, 恶性肿瘤, 近距离治疗

Abstract:

Malignant tumors are serious threat to human health. The way to treat cancer include surgery, radiotherapy and chemotherapy, etc. ¹²⁵I is a radionuclide with a longer half-life (T_1/2=59.7 d) and release of low-energy gamma rays (27 keV) by electron capture. ¹²⁵I is suitable for brachy therapy in nuclear medicine and could be prepared as seed source widely used in clinic. ¹²⁵I-seeds could be implanted into tumor tissue by surgical implantation. The therapeutic methods are simple and less invasive and have broad application prospects which show significant curative effect in lung cancer, pancreatic cancer, prostate cancer and other solid tumors. This paper reviews the research progress of the preparation of ¹²⁵I and ¹²⁵I-seeds, the ¹²⁵I-seeds in treatment different types of tumors. The development trend for of ¹²⁵I-seeds sources application is also been discussed.

Key words: ¹²⁵I-seed, brachy therapy, malignant tumour, radiotherapy

黄金铭;于宁文. ¹²⁵I放射性粒子治疗癌症研究进展[J]. 同位素, 2020, 33(3): 186-198.

HUANG Jinming;YU Ningwen. Progress of Permanent Seed Implantation Using ¹²⁵I-seeds for Cancer Therapy[J]. Journal of Isotopes, 2020, 33(3): 186-198.

参考文献

［1］于宁文，沈亦佳，吴宇轩，等. 用于堆照制备¹²⁵I的循环回路系统调试［J］. 同位素，2018，31（2）:104-109. Yu Ningwen, Shen Yijia, Wu Yuxuan, et al. Commissioning for ¹²⁵I production loop simulation system by reactor irradiation［J］. Journal of Isotopes, 2018, 31（2）: 104-109(in Chinese).
［2］秦传洲，李梅，钟正坤，等. 放射性¹²⁵I种子源自动生产装置的研制［J］. 原子能科学技术，2016，50（1）:188-192.Qin Chuanzhou, Li Mei, Zhong Zhengkun, et al. Development of autoproduct facility for ¹²⁵I Source［J］. Atomic Energy Science and Technology, 2016, 50（1）: 188-192(in Chinese).
［3］何佳恒，姜林，党宇峰，等. ¹²⁵I种子源制备相关技术研究［J］. 原子能科学技术，2012，46（1）：124-128.He Jiaheng, Jiang Lin, Dang Yufeng, et al. Sequent research on ¹²⁵I seed source［J］. Atomic Energy Science and Technology, 2012, 46（1）: 124-128(in Chinese).
［4］梅雪松，滕立才，鲁彤，等. 放射性种子源源芯焊封工艺技术研究［J］. 黑龙江科学，2015，1（6）：8-9.Mei Xuesong, Teng Licai, Lu Tong, et al. Study on radioactive seed source core welding technology［J］. Heilongjiang Science, 2015, 1（6）: 8-9(in Chinese).
［5］王巍，邓雪松，乔来成，等. ¹⁰³Pd种子源的研制与应用［J］. 现代临床医学生物工程学杂志，2001，7（6）：422-425.Wang Wei, Deng Xuesong, Jiao Laicheng, et al. The development and application of ¹⁰³Pd seeds［J］. Journal of Modern Clinical Medical Bioengineering, 2001, 7（6）: 422-425(in Chinese).
［6］张旭光，山常起，马旺扣，等. ¹⁹²Ir颗粒源的制造和辐射剂量检测［J］. 中华核医学，2004，24（2）：80-81.Zhang Xuguang, Shan Changqi, Ma Wangkou, et al. Manufacture of 192Ir particle source and radiation dose detection［J］. Chinese Journal of Nuclear Medicine, 2004, 24（2）: 80-81(in Chinese).
［7］潘建基，吴君心. 近距离放射治疗的临床应用进展［J］. 中国癌症杂志,2006，16（6）：459-463.Pan Jianji, Wu Junxin. Progress of clinical brachytherapy application［J］. China Oncology, 2006, 16（6）: 459-463(in Chinese).
［8］李忠勇，高惠波，金小海，等. 近距离治疗肿瘤的放射性粒子研究进展［J］. 同位素，2011，24（2）：118-123.Li Zhongyong, Gao Huibo, Jin Xiaohai, et al. Research progress in radioactive seed for brachytherapy［J］. Journal of Isotopes, 2011, 24（2）: 118-123(in Chinese).
［9］王志远. 近距离放射治疗技术的进展［M］. 国外医学生物医学工程分册，1999，22（3）：172-176.
［10］Hu Y, Qi E, Liu F, et al. The application of three-dimensional visualized seed planning and navigation system in ¹²⁵I implantation for pancreatic cancer［J］. Onco Targets There, 2018,11: 619-627.
［11］陈永祥，陈家华. 放射性粒子近距离治疗肿瘤研究进展［J］. 河北医学，2006，28（11）：1093-1094.Chen Yongxiang, Chen Jiahua. The development of brachytherapy using raidoactive seeds［J］.Hebei Medical Journal, 2006, 28（11）: 1093-1094(in Chinese).
［12］Kazuto I, Shiro S, Yorozu A, et al. Nationwide Japanese prostata cancer outcome study of permanent iodine-125 seed implantation(J-POPS): first analysis on survival［J］.International Journal of Clinical Oncology, 2018, 23: 1148-1159.
［13］Brinzan D M, Constantin T V, Radu T M, et al. LDR I-125 brachytherapy as treatment for intracapsular prostate cancer［J］. Eur Urol Suppl, 2016, 15(11): e1404.
［14］Isabelle K, Karin S, Ignace B, et al. 125I brachycherapy in younger prostate cancer patients［J］. Strahlenter Onkol, 2017, 193: 707-713.
［15］张国辉，朱志超，张水文，等. 间歇内分泌治疗联合国¹²⁵I放射性粒子植入治疗局限性前列腺癌的临床观察［J］. 现代泌尿外科杂志，2012，17（1）：28-31.Zhang Guohui, Zhu Zhichao, Zhang Shuiwen, et al. Clinical observation: the clincal efficacy of the combined intermittent endocrinal therapy and implantation of radioactive particle in treating localized prostate cancer［J］. J Mod Urol, 2012, 17（1）: 28-31(in Chinese).
［16］Takashi K, Akiko K, Chisato T, et al. Long-term outcome of low dose rate brachytherapy with I-125 seeds as a monotherapy for high-risk prostate cancer patients［J］. Brachytherapy, 2017, 16: S55.
［17］赵全兵，李启忠. 放射性粒子植入治疗前列腺癌的进展［J］. 现代泌尿生死肿瘤杂志，2009（1）：53-55.Zhao Quanbing, Li Qizhong. The development of brachytherapy in prostate cancer［J］. J Contemp Urol Reprod Oncol, 2009（1）: 53-55(in Chinese).
［18］王旭亮，于志坚，水兵，等. 粒子植入近距离放射治疗前列腺癌的进展［J］. 中国乡村医药杂志，2013，20（14）：78-80.Wang Xuliang, Yu Zhijian, Shui Bing, et al. Progress of brathytherapy in prostate cancer［J］. Chinese Journal of Rural Medicine and Pharmacy, 2013, 20（14）: 78-80(in Chinese).
［19］Freiberger C, Berneking V, Vogeli T, et al. Ouality of life up to 10 years after external beam radiotherapy and/or brachytherapy for prostate cancer［J］.Brachytherapy, 2018, 17: 517-523.
［20］谢和民. CT引导放射性碘125粒子治疗非小细胞肺癌疗效观察［J］. 临床合理用药，2016，9（7）：104-105.Xie Hemin. CT-guided radioactive iodine-125 particles in the treatment of non-small cell lung cancer［J］. Chinese Journal of Clinical Rational Drug Use, 2016, 9（7）: 104-105(in Chinese).
［21］钟辉，黄文，张祖建，等. CT引导下¹²⁵I放射性粒子组织间植入对非小细胞肺癌患者血清肿瘤标志物及瘤体大小的影响［J］. 标记免疫分析与临床，2018，25（5）：703-706.Zhong Hui, Huang Wen, Zhang Zujian.Effect of CT guided interstitial implantation of ¹²⁵I radioactive particles on serum tumor markers and tumor volume in patients with non-small cell lung cancer［J］. Labeled Immunoassays and Clinical Medicine, 2018, 25（5）: 703-706(in Chinese).
［22］Jiao D, Ren K W, Shui S, et al. Clinical role of guidance by C-arm CT for ¹²⁵I brachytherapy on lulmonary tumors［J］. Radiol Med, 2017, 122: 829-836.
［23］陈婧多，黄辉. 放射性¹²⁵I粒子植入治疗肺癌的现状及进展［J］. 世界最新医学信息文摘，2017，17（26）：50-51.Chen Jingduo, Huang Hui. Current status and progress of radioactive ¹²⁵I seed implantation in the treatment of lung cancer［J］.World Latest Medicine, 2017, 17（26）: 50-51(in Chinese).
［24］谢红，吴敬波，向莉. 用近距离放射疗法治疗非小细胞肺癌的研究进展［J］. 当代医药论丛，2016，14（1）：15-17.Xie Hong, Wu Jingbo, Xiang Li. Progress in brachytherapy for nonsmall cell lung cancer［J］.Contemporary Medical Symposium, 2016, 14（1）: 15-17(in Chinese).
［25］游琴，韩世龙，胡娜娜，等. 放射性¹²⁵I粒子治疗晚期肺癌的疗效分析［J］. 同济大学学报（医学版），2017，38（1）：57-60.You Qin, Han Shilong, Hu Nana, et al. Efficacy of ¹²⁵I radioactive particle implantation in treatment of advanced lung cancer［J］. Journal of Tongji University (Medical) Science, 2017, 38（1）: 57-60(in Chinese).
［26］蒲德利，廖江荣. 经支气管镜植入放射性¹²⁵I粒子治疗中央型肺癌合并肺不张疗效观察［J］. 现代医药卫生，2017，33（23）：3625-3627.Pu Deli, Liao Jiangrong.Clinical observation of radioactive ¹²⁵I particles implanted through bronchoscope in the treatment of central lung cancer complicated with atension［J］.Journal of Modern Medicine and Health, 2017, 33（23）: 3625-3627(in Chinese).
［27］赵诚.¹²⁵I粒子联合氟尿嘧啶缓释粒子治疗肺癌疗效观察［J］. 中国继续医学教育，2015，24（7）：173-174.Zhao Cheng. Therapeutic effect of ¹²⁵I particles combined with fluorouracil sustained-release particles in the treatment of lung cancer［J］. China Continuing Medical Education, 2015, 24（7）: 173-174(in Chinese).
［28］Huo X D, Wang H X, Wang L, et al. Implantation of computed tomography-guided Iodine-125 seeds in combination with chemotherapy for the treatment of stage Ⅲ non-small cell lung cancer［J］. J Contemp Brachytherapy, 2017, 9(6): 527-534.
［29］Yu X J, Li J, Zhong X, et al. Combination of Iodine-125 brachytherapy and chemotherapy for locally recurrent stage Ⅲ non-small cell lung cancer after concurrent chemoradiotherapy［J］ .Biomed Central Cancer , 2015 , 15: 656.
［30］曾德筠. TACE联合¹²⁵I放射性粒子治疗原发性肝癌合并门静脉癌栓的研究［J］ . 齐齐哈尔医学院学报，2014，35（17）：2519-2521.Zeng Dejun. TACE combined with ¹²⁵I radioactive particles in the treatment of primary hepatocellular carcinoma complicated with portal vein tumor thrombus［J］. Journal of Qiqihar Medical College, 2014, 35（17）: 2519-2521(in Chinese).
［31］黄文薮，蔡明岳，曾昭吝，等. TACE联合¹²⁵I放射性粒子植入治疗肝细胞癌门静脉癌栓［J］. 介入放射学杂志，2015，24（6）：488-493.Huang Wensou, Cai Mingyue, Zeng Zhaolin, et al. Transarterial chemoembolization combined with CT-gudied ¹²⁵I seed implantation for the treatment of hepatocellular carcinoma associated with portal vein tumor thrombus［J］. J Intervent Radiol, 2015, 24（6）: 488-493.
［32］沈丽荣，白杨，张启周. CT导引下¹²⁵I粒子植入联合TACE治疗原发性肝癌合并门脉癌栓［J］. 牡丹法医学院学报，2015，36（4）：39-41.Shen Lirong, Bai Yang, Zhang Qizhou, et al. CT-guided ¹²⁵I seed implantation combined with TACE in the treatment of primary hepatocellular carcinoma with portal vein cancer thrombus［J］. Journal of Mudanjiang Medical University, 2015, 36（4）: 39-41(in Chinese).
［33］Li J, Xie Q J, Wang W, et al. CT-guided implantation of ¹²⁵I seeds (permanent brachytherapy) for metastatic tumors of the hepatic portal system: effectiveness and safety in 13 patients［J］.Brachytherapy , 2016 , 15: 224-230.
［34］Zhang Z H, Zhang W, Gu J Y, et al. Treament of hepatocellular carcinoma with tumor thrombus with use of Iodine-125 seed strand implantation and transarterial chemoembolization: a propensityscore analysis［J］.J Vasc Interv Radiol, 2018, 29: 1085-1093.
［35］Yuan D, Gao Z, Zhao J, et al. ¹²⁵I seed implantation for hepatocellular carcinoma with potal vein tumor thrombus: a systematic revive and meta-analysis［J］. Brachytherapy, 2019, 18(4): 521-529.
［36］黄飞龙，刘小方，黄生传，等. 腹腔镜下碘-125粒子植入治疗不可切除胰腺癌的临床效果［J］. 临床医学研究与实践，2018，10：4-9.Huang Feilong, Liu Xiaofang, Huang Shengchuan, et al. Clinical effect of laparoscopic Iodine-125 particle implantation in the treatment of iresectable pancreatic cancer［J］. Clinical Research and Practice, 2018, 10: 4-9(in Chinese).
［37］郝伟远，俞炎平，王小红，等. CT引导下¹²⁵I粒子植入联合替吉奥治疗中晚期胰腺癌的临床应用［J］. 中国现代医生，2015，53（35）：66-69.Hao Weiyuan, Yu Yanping, Wang Xiaohong, et al. Application and reliability of CT-guided ¹²⁵I seed implantation combined with TS-1 for the treatment of middle-late pancreatic carcinoma［J］.China Modern Doctor, 2015, 53（35）: 66-69(in Chinese).
［38］Han Q L, Deng M H, Lv Y, et al. Survival of patients with advanced pancreatic cancer after Iodine-125 seeds implantation brachytherapy［J］.Systematic Review and Meta-analysis, 2017, 96(5): 1-7.
［39］Sun X T, Lu Z, Min M, et al. An endoscopic ultrasonography-guided interstitial brachytherapy based special treatment-planning system for unresectable pancreatic cancer［J］. Oncotarget, 2017, 8(45): 79099-79110.
［40］Wang W J, Wang Y Z, Li Zheng, et al. Iodine-125 seed implantation with and percutanerous stenting in the treatment of pancreatic cancer with obstructive jaundice［J］. Brachytherapy, 2017, 16: S91.
［41］Liu B, Zhou T, Wang J, et al. Percutaneous GT-guided Iodine-125 seeds implantation for unresectable pancreatic cancer［J］. Brachytherapy, 2016, 15: S141.
［42］Yang M J, Yan Z P, Luo J J, et al. A pilot study of intraluminal brachytherapy using 125I seed strand for locally advanced pancreatic ductal adenocarcinoma with obstructive jaundice［J］. Brachytherapy, 2016, 15: 859864.
［43］中国医师协会放射性粒子植入技术专家委员会. 放射性¹²⁵I粒子植入治疗胰腺癌中国专家共识［J］. 临床肝胆杂志，2018，34（4）：716-723.Expert Committee on Radioactive Particle Implantation Technology of Chinese Medical Association. Chinese expert consensus on treatment of pancreatic cancer by radioactive ¹²⁵I particle implantaion［J］. Journal of Clinical Hepatology, 2018, 34（4）: 716-723(in Chinese).
［44］刘玉，刘晓娜，高维青，等. 联合应用DCE-MRI和¹⁸F-FDG PET/CT监测¹²⁵I粒子短距离放疗对胰腺癌移植瘤的疗效［J］.中国医学物理学杂志，2017，34（1）：1-6.Liu Yu, Liu Xiaona, Gao Weiqing, et al. Combining DCE-MRI and ¹⁸F-FDG PET/CT for monitoring the efficacy of ¹²⁵I seed brachytherapy in nude mice bearing pancreatic cancer xenografts［J］. Chinese Journal of Medical Physics, 2017, 34（1）: 1-6(in Chinese).
［45］罗东，唐能，刘国栋，等. ¹²⁵I放射性粒子植入近距离治疗不可切除胰腺癌的现状与进展［J］. 中国普通外科杂志，2017，26（9）：1193-1201.Luo Dong, Tang Neng, Liu Guodong, et al. Iodine-125 radioactive seed implantation brachytherapy for unresectable pancreatic cancer: current status and progress［J］. Chinese Journal of General Surgery, 2017, 26（9）: 1193-1201(in Chinese).
［46］陶为杰，石小举，王广义. ¹²⁵I放射性粒子植入治疗不可切除胰腺癌的研究进展［J］. 临床肝胆病杂志，2016，32（5）：972-976.Tao Weijie, Shi Xiaoju, Wang Guangyi, et al. Research advances in ¹²⁵I radioactive seed implantation for treatment of unresectable pancreatic cancer［J］. J Clin Hepatol, 2016, 32（5）: 972-976(in Chinese).
［47］江旭，杨继金，李慧. 碘-125粒子植入近程放疗在肝胆胰恶性肿瘤中的应用［J］. 临床肝胆病杂志，2016，32（12）：2300-2304.Jiang Xu, Yang Jijin, Li Hui, et al. Clinical effect of brachytherapy with ¹²⁵I seed implantation in treatment of malignant hepatopancreatobiliary［J］. J Clin Hepatol, 2016, 32（12）: 2300-2304(in Chinese).
［48］吴维霞，周志刚，邢明泉. CT引导下¹²⁵I放射性粒子植入术在不可切除胰腺癌治疗中的应用现状及展望［J］. 中华临床医师杂志，2018，12（3）：181-184.Wu Weixia, Zhou Zhigang, Xing Mingquan, et al. Application and prospect of CT-guided ¹²⁵I radioactive particle implantation in treatment of unresectable pancreatic cancer［J］. Chinese Journal of Clinicians, 2018, 12（3）: 181-184(in Chinese).
［49］王颖. 胰腺癌放射性核素内照射治疗现状及进展［J］. 中国普通外科杂志，2015，24（3）：408-412.Wang Ying. Internal radionuclide therapy in pancreatic cancer: current status and progress［J］. Chinese Journal of General Surgery, 2015, 24（3）: 408-412(in Chinese).
［50］蔡勇. 放射粒子植入疗法在早期乳腺癌患者保乳治疗中的疗效［J］. 医疗服务标准前研究，2018，9（11）：46-48.Cai Yong. Effect analysis of radioactive particle implantation in breast conserving treatment for early breast cancer patients［J］. China Health Standard Management, 2018, 9（11）: 46-48(in Chinese).
［51］肖欢，潘卫民，高炳玉，等. ¹²⁵I粒子术中植入在早期乳腺癌患者治疗中的临床价值［J］. 中国热带医学，2015，15（11）：1365-1368.Xiao Huan, Pan Weimin, Gao Bingyu, et al. Clinical value of ¹²⁵I particles intraoperative implantation in therapy of early breast cancer patients［J］. China Tropical Medicine, 2015, 15（11）: 1365-1368(in Chinese).
［52］丁战玲，于滢华，杨伟萍，等. 超声引导放射性粒子植入治疗复发转移及局部晚期乳腺癌的研究［J］. 重庆医学，2016，45（3）：410-412.Ding Zhanling, Yu Yinghua, Yang Weiping, et al. Ultrasound-guided radioactive seed implantation for recurrent and metastatic breast cancer and locally advanced breast cancer［J］. Chongqing Medical, 2016, 45（3）: 410-412(in Chinese).
［53］王妍，吴杰，孙涛，等. CT引导下¹²⁵I放射性粒子植入治疗乳腺癌骨转移患者的临床效果［J］. 广西医学，2018，40（14）：1540-1545.Wang Yan, Wu Jie, Sun Tao, et al. Clinical effect of CT-guided implantation of Iodine-125 seeds on patients with bone metastasis of breast cancer［J］. Guangxi Medical, 2018, 40（14）: 1540-1545(in Chinese).
［54］闫雷，谢涛，吉喆，等. 放射性粒子植入在乳腺癌治疗中的应用［J］. 癌症进展，2018，16（6）：686-693.Yan Lei, Xie Tao, Ji Zhe, et al. Application of radioactive seed implantation in the treatment of breast cancer［J］. Oncology Progress, 2018, 16（6）: 686-693(in Chinese).
［55］郑丹，袁志平，林川，等. ¹²⁵I粒子植入手术和放化疗后复发转移直肠癌疗效探析［J］. 深圳中西医结合杂志，2015，25（22）：6-7.Zheng Dan, Yuan Zhiping, Lin Chuan, et al. Recurrence and metastasis of rectal cancer after implantation of ¹²⁵I particles and chemotherapy［J］. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2015, 25（22）: 6-7(in Chinese).
［56］王溪，韩今华，李云峰，等. 热疗联合¹²⁵I粒子治疗复发性直肠癌的近期疗效评价［J］. 吉林大学学报（医学版），2017，43（5）：963-966.Wang Xi, Han Jinhua, Li Yunfeng, et al. Observation on short-term efficacy of thermal-therapy combined with ¹²⁵I particles in treatment of recurrent rectal cancer［J］. Journal of Jilin University(Medicine Edition) , 2017, 43（5）: 963-966(in Chinese).
［57］何美林，罗开元. 放射性粒子植入治疗结直肠癌的研究进展［J］. 医学综述，2012，18（3）：359-361.He Meilin, Luo Kaiyuan. Research progress of implantation of radioactive particles treating colorectal cancer［J］. Medical Recapitulate, 2012, 18（3）: 359-361(in Chinese).
［58］杨轩璇，羌伟光，李蓝东，等. ¹²⁵I放射性粒子植入联合化疗治疗直肠癌术后辅助放疗后局部复发［J］. 肿瘤基础与临床，2016，29(5):396-400.Yang Xuanxuan, Qiang Weiguang, Li Landong, et al. ¹²⁵I-seed implatation plus chemotherapy for locally recurrent rectal cancer with adjuvant radiotherapy［J］. Journal of Basic and Clinical Oncology, 2016, 29(5): 396-400(in Chinese).
［59］周芊，雷新. 直肠癌近距离治疗放疗现状［J］. 现代医药卫生，2017，33（14）：2149-2151.Zhou Qian, Lei Xin. Current status of brachytherapy for rectal cancer［J］. Journal of Modern Medicine and Health, 2017, 33（14）: 2149-2151(in Chinese).
［60］孙文. 放射性¹²⁵I粒子植入治疗消化道肿瘤的研究进展［J］. 中国微创外科杂志，2018，18（9）：842-845.Sun Wen. Progress of radioactive ¹²⁵I seed implantation in the treatment of digestive tract tumors［J］ . Chinese Journal of Minimally Invasive Surgery, 2018, 18（9）: 842-845(in Chinese).
［61］张念华，陈高峰，李寿杰，等. CT引导下植入¹²⁵I放射粒子联合化疗治疗结直肠癌肝转移的疗效分析［J］. 实用中西医结合临床，2016，16（10）：1-3.Zhang Nianhua, Chen Gaofeng, Li Shoujie, et al. Clinical observation of CT guided ¹²⁵I implantation combined with chemotherapy in treating liver metastasis of colorectal cancer［J］. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine, 2016, 16（10）: 1-3(in Chinese).
［62］刘艳，李清春，侯睿智，等. 放射性粒子¹²⁵I植入治疗晚期结直肠癌9例分析［J］. 中国普外基础与临床杂志，2015，22（10）：1222-1225.Liu Yan, Li Qingchun, Hou Ruizhi, et al. Radioactive seeds Iodine-125 implantation in treatment of advanced colorectal cancer: report of nine cases［J］. Chinese Journal of Bases and Clinics in General Surgery, 2015, 22（10）: 1222-1225(in Chinese).
［63］薛吉山. CT导向下¹²⁵I粒子组织间植入治疗难治性直肠癌盆腔复发的临床观察［J］. 中国药物经济学，2015，2：148-149.Xue Jishan. Clinical observation on treatment of ¹²⁵I guided CT seed interstitial implantation for refractory pelvic recurrence of rectal cancer［J］. China Journal of Pharmaceutical Economics, 2015, 2: 148-149(in Chinese).
［64］任庆，熊锐华，田秀荣，等. ¹²⁵I粒子植入联合化疗治疗结直肠癌术后肝转移的临床研究［J］. 肿瘤防治研究，2014，41（6）：653-656.Ren Qing, Xiong Ruihua, Tian Xiurong, et al. ¹²⁵I seed implantation combined with chemotherapy for colorectal cancer［J］. Cancer Research on Prevention and Treatment, 2014, 41（6）: 653-656(in Chinese).
［65］程琳，何闯，刘云，等. 放射性¹²⁵I粒子联合经皮椎体成形术治疗椎体转移瘤的应用研究进展［J］. 局解手术学杂志，2017，26（7）：535-538.Cheng Lin, He Chuang, Liu Yun, et al. Progress on application of ¹²⁵I seeds and percutaneous vertebraplasty for vertebral metastases［J］. J Reg Anat Oper Surg, 2017, 26（7）: 535-538(in Chinese).
［66］谢涛，崔佳宁，闫雷，等. 放射性¹²⁵I粒子植入治疗在椎体转移瘤中的应用进展［J］. 癌症进展，2018，16（7）：801-811.Xie Tao, Cui Jianing, Yan Lei, et al. Advances in the application of radioactive ¹²⁵I seed implantation in the treatment of vertebral metastases［J］. Oncology Progress, 2018, 16（7）: 801-811(in Chinese).
［67］关键，袁振超，刘斌. ¹²⁵I粒子治疗脊柱转移瘤的研究进展［J］. 中华肿瘤防治杂志，2016，23（20）：1392-1397.Guan Jian, Yuan Zhenchao, Liu Bin. Research progress of ¹²⁵I seeds implantation for metastatic spinal tumors［J］. Chinese Journal of Cancer Prevention and Treatment, 2016, 23（20）: 1392-1397(in Chinese).
［68］邱国钦，许丽贞，陈玉强，等. ¹²⁵I放射性粒子植入联合椎体成形术在椎体转移瘤中的应用［J］. 影像诊断与介入放射学，2015，24（1）：74-79.Qiu Guoqin, Xiu Lizhen, Chen Yuqiang, et al. Value of percutaneous vertebroplasty combined with radioactive seed implantation in the treatment of vertebral metastatis［J］. Diagnostic Imaging and Interventional Radiology, 2015, 24（1）: 74-79(in Chinese).
［69］邱国钦，许丽贞，林智才，等. 椎体成形术联合放射性粒子治疗椎体转移癌的临床观察［J］. 临床肿瘤学，2014，19（8）：723-727.Qiu Guoqin, Xiu Lizhen, Lin Zhicai, et al. Clinical observation of percutaneous vertebroplasty combined with radioactive seeds in the treatment of patients with vertebral metastatic Carcinoma［J］. Chinese Clinical Oncology, 2014, 19（8）: 723-727(in Chinese).
［70］肖全平，吴春根，王涛，等. 经皮骨成形术联合¹²⁵I粒子植入治疗骨转移瘤临床应用［J］. 临床放射学杂志，2015，34（4）：624-629.Xiao Quanping, Wu Chungen, Wang Tao, et al. Clinical application of percutanesous vertebroplasty combined with ¹²⁵I seeds implantation in treating bone metastases［J］. Journal of Clinical Radiology, 2015, 34（4）: 624-629(in Chinese).
［71］王骏臣，胡玮，余新林，等. 经皮椎体成形术联合¹²⁵I放射粒子植入术治疗椎体转移瘤的效果评价［J］. 吉林大学学报（医学版），2017，43（6）：1243-1247.Wang Junchen, Hu Wei, Yu Xinlin, et al. Effectiveness evaluation on percutaneous vertebroplasty combined with ¹²⁵I radioactive particle implantation in treatment of vertebral metastasis［J］. Journal of Jilin Universtiy(Medicine Edition), 2017, 43（6）: 1243-1247(in Chinese).
［72］He C, Li Y, Huang X Q, et al. Clinical efficacy of CT-guided ¹²⁵I seed implantation therapy for the patients with vertebral metastasis［J］. Brachytherapy, 2017, 16: S95.
［73］孙宾，熊伟，李雪松，等. PVP联合放射性¹²⁵I粒子植入治疗椎体及椎旁肿瘤患者的疗效与安全性分析［J］. 医疗装备，2016 ，29（10）：31-32.Sun Bin, Xiong Wei, Li Xuesong, et al. Efficacy and safety of PVP combined with radioactive ¹²⁵I seed implantation in the treatment of vertebral and paravertebral tumors［J］. Chinese Journal of Medical Device, 2016 , 29（10）: 31-32(in Chinese).
［74］Cao Q Q, Wang H, Meng N, et al. CT-guidance interstitial 125I odine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors［J］. Radiation Oncology, 2014(9): 301.
［75］中国抗癌协会癌症康复与姑息治疗专业委员会. 难治性癌痛专家共识［J］. 中国肿瘤临床，2017，44（16）：787-793.Professional Committee on Cancer Rehabilitation and Palliative Therapy of China Anti-Cancer Association. Expert consensus on refractory cancer pain［J］. Chinese Journal of Clinical Oncology, 2017, 44（16）: 787-793(in Chinese).
［76］马红梅. 椎体转移瘤疼痛治疗的研究［J］. 世界最新医学信息文摘，2016，16（51）：25.Ma Hongmei.Study on pain treatment of vertebral metastases［J］. World Latest Medicine Information, 2016, 16（51）: 25(in Chinese).

[1]	滕婧静;眭国平;高铮亚;陈建新;陆逊;肖瑶;孙训. ¹²⁵I放射性粒子源水中吸收剂量的修正方法探讨[J]. 同位素, 2013, 26(4): 249-252.
[2]	李忠勇;高惠波;金小海;陈大明. 近距离治疗肿瘤的放射性粒子研究进展[J]. 同位素, 2011, 24(2): 118-123.
[3]	胡疏 ;成先义 ;高宙 ;尹为华 ;孙德胜 ;陈俊辉 ;贾少微 . ¹²⁵I粒子组织间植入近距离治疗恶性肿瘤[J]. 同位素, 2011, 24(1): 34-38.
[4]	作者. 肺部恶性肿瘤组织摄取~(99)Tc~m-MIBI与Pgp表达的相关性[J]. 同位素, 2004, 17 (3 ): 157-157 .
[5]	作者. ~(153)Sm-EDTMP和博宁治疗恶性肿瘤骨转移骨痛的疗效比较 [J]. 同位素, 2002, 15 (2 ): 111-111 .
[6]	作者. 放射性核素治疗的现状与未来 [J]. 同位素, 2000, 13 (2 ): 97-97 .
[7]	作者. ~(90)Y、~(32)P-GTMS 介入治疗恶性肿瘤的实验研究与初步临床应用 [J]. 同位素, 1998, 11 (2 ): 43-49 .
[8]	作者. CEA、SF、β_2-MG、AFP、CG RIA联合检测对恶性肿瘤的诊断价值 [J]. 同位素, 1993, 6 (4 ): 234-234 .
[9]	作者. ~(99)Tc~m-Dx恶性肿瘤病人淋巴显像的意义 [J]. 同位素, 1993, 6 (3 ): 183-183 .

¹²⁵I放射性粒子治疗癌症研究进展

Progress of Permanent Seed Implantation Using ¹²⁵I-seeds for Cancer Therapy

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