同位素 ›› 2019, Vol. 32 ›› Issue (5): 360-374.DOI: 10.7538/tws.2018.youxian.023

• 综述 • 上一篇    

68Ga标记药物研究进展

郭志德;张现忠;杜进   

  1. 中国原子能科学研究院 同位素研究所,北京102413;厦门大学 分子影像暨转化医学研究中心,福建 厦门361102;中国同辐股份有限公司,北京100045
  • 出版日期:2019-10-20 发布日期:2019-09-25

The Research Progress of 68Ga Generator and 68Ga Radiopharmaceuticals

GUO Zhide;ZHANG Xianzhong;DU Jin   

  1. Department of Isotope, China Institute of Atomic Energy, Beijing 102413, China;Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China; China Isotope & Radiation Corporation, Beijing 100045, China
  • Online:2019-10-20 Published:2019-09-25

摘要:

正电子发射型计算机断层显像(positron emission tomography, PET)是核医学领域重要的诊断及显像工具,在基础医学诊断、新药研发和疗效评价等各方面发挥越来越重要作用。18F是PET显像最常用的核素,但18F需要加速器生产。68Ga为PET显像核素,可以从长寿命的68Ge/68Ga发生器装置获得,不必依赖加速器。随着配位化学的发展,各种双功能螯合剂用于68Ga的标记,可将68Ga与多种化学结构及生物分子连接并且可以药盒化68Ga标记药物。本文主要介绍近期68Ga标记放射性药物的研究进展。

关键词: PET显像, 68Ga发生器, 68Ga标记药物

Abstract:

Positron emission tomography (PET) is an important diagnosis and imaging tool for nuclear medicine, and playing an increasing part in fundamental medicine, new drug research and clinical effect assessment, etc. 18F is the most common radionuclide for PET imaging, which is produced in a cyclotron. 68Ga is a PET imaging radionuclide of increasing concern, and is gained from long-lived 68Ge/68Ga generator systems. The use of 68Ga does not demandan on-site cyclotron, which provide a convenient method for researchers. With the development of coordination chemistry, a variety of bifunctional chelators have been developed for 68Ga labeling, which allow the convenient coupling tomany chemical structures and biomolecules. Kitformulated preparation is another advantage for 68Ga radiopharmaceuticals. This review presents the developments of the 68Ga based radiopharmaceuticals.

Key words: positron emission tomography, 68Ga generator, 68Ga radiopharmaceuticals