同位素 ›› 2018, Vol. 31 ›› Issue (3): 188-197.DOI: 10.7538/tws.2018.31.03.0188

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碘-124的生产、标记及在肿瘤PET分子影像的应用

李立强;王风;刘特立;朱华;杨志   

  1. 北京大学肿瘤医院暨北京市肿瘤防治研究所 核医学科 恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142
  • 出版日期:2018-06-20 发布日期:2018-06-07

Production of Iodine-124 and Its Application in PET Molecular Imaging

LI Liqiang;WANG Feng;LIU Teli;ZHU Hua;YANG Zhi   

  1. Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
  • Online:2018-06-20 Published:2018-06-07

摘要:

124I是一种半衰期较长的正电子核素(T1/2=4.2 d),由于其生产工艺要求较高、复杂的衰变纲图以及辐射出的超高能量γ射线,在过去很长一段时间里限制了其临床应用。如今,随着回旋加速器生产核素技术的进步及正电子发射型计算机断层显像(PET)技术在肿瘤及药物药代动力学等研究中应用不断拓展,使得124I核素标记的化合物成为具有应用价值的核医学PET分子探针。本文主要对124I正电子核素的核性质、生产方式、常规标记方法以及在PET分子影像方面的临床应用进行阐述。

关键词: 碘-124, 正电子发射型计算机断层显像, 肿瘤, 分子影像, 固体靶核素生产

Abstract:

Iodine-124 (124I) is an isotope for positron as well as unique chemical properties and convenient halflife of 4.2 days. Its modes of decay are 74.4% electron captureand 25.6% positron emission. Until recently, 124I is not considered to be an attractive isotope for medical application owing to its complex radioactive decay scheme and the high-energy gamma rays. 124I can be made by numerous nuclear reactions via a cyclotron. The most common starting material is 124Te and 124I that can decay to 124Te. 124I as sodium iodine form can be used to image the thyroid and corresponding tumor using positron emission tomography (PET) directly. The 124I nuclide can be chemically bonded to a pharmaceutical to form a positron-emitting radiopharmaceutical. Radioiodination of 124I can be efficiency attached to small molecular, peptide or antibody within radiochemistry labs. Nowadays, due to the increasing application of PET in medical oncology, pharmacokinetics and drug metabolism, 124I-labeled radiopharmaceuticals are now becoming one of the most useful tools for PET imaging. 124I-labeled monoclonal antibodies (mAbs) are being used for clinical immuno-PET. Among them, 124I-cG250 accurately identifies clear-cell renal carcinoma attracting clinical attentions. Based on those progress, this review outlined the physical property, production and application of 124I in PET molecular imaging.

Key words: iodine-124, positron emission-computed tomography, tumor, molecular imaging, solid target nuclide production