医用同位素生产现状及技术展望

doi:10.7538/tws.2016.29.02.0116

摘要/Abstract

摘要：

本文概述同位素生产技术，介绍医用同位素生产现状，分析供求关系和面临的问题，提出医用同位素的发展趋势和技术展望。随着核医学迅速发展，医用同位素在疾病诊断和临床治疗中发挥越来越重要的作用。我国人口基数庞大，国内医用同位素主要依赖进口。建立产能高、安全性好的医用同位素生产堆有望突破核医学的发展瓶颈。传统反应堆同位素生产技术仍有优化空间，新型反应堆同位素生产技术亟待研究和推广，不依赖反应堆的同位素生产技术仍具有一定的市场前景。

关键词: 医用同位素, 反应堆, 加速器, 核素发生器

Abstract:

The isotope production technology was overviewed, including traditional and newest technology. The current situation of medical isotope production was introduced. The problems faced by isotope supply and demand were analyzed. The future development trend of medical isotopes and technology prospect were put forward. As the most populous country, nuclear medicine develops rapidly, however, domestic isotope mainly relies on imports. The highly productive and relatively safe MIPR is expected to be an effective way to breakthrough the bottleneck of the development of nuclear medicine. Traditional isotope production technologies with reactor can be improved. It's urgent to research and promote new isotope production technologies with reactor. Those technologies which do not depend on reactor will have a bright market prospects.

Key words: medical isotopes, reactor, accelerator, nuclide generator

高峰;林力;刘宇昊;马兴均. 医用同位素生产现状及技术展望[J]. 同位素, 2016, 29(2): 116-120.

GAO Feng;LIN Li;LIU Yu-hao;MA Xing-jun. Production Situation and Technology Prospect of Medical Isotopes[J]. Journal of Isotopes, 2016, 29(2): 116-120.

参考文献

［1］Glenn D, Heger A S, Hladik W B. Comparison of characteristics of solution and conventional reactors for ⁹⁹Mo production［J］. Nuclear Technology, 1997, 118: 142-150.
［2］Sciuto R, Festa A, Pasqualonir R, et al. Metastatic bone pain palliation with 89Sr and¹⁸⁶Re-HEDP in breast cancer patients［J］. Br Cancer Res Treat, 2001, 66(2): 101-109.
［3］Lane J A, Macpherson H G, Maslan F. Fluid Fuel Reactors［M］. Massachusetts: Addison-Wesley Publishing Co Inc, 1958.
［4］Method of ⁸⁹Sr medical radioisotope production: US, 538333［P］. 2002-01-22.
［5］Souta F J, Kimpland R H. Analysis of the effects of radiolytic-gas bubbles on the operation of solution reactors for the production of medical isotopes［J］. Nuclear Science and Engineer, 2005, 150: 322-335.
［6］Chuvilin D Y, Khvostionov V E, Markovskij D V, et al. Production of ⁸⁹Sr in solution reactor［J］. Applied Radiation and Isotopes, 2007, 65: 1087-1094.
［7］Ball R M. Characteristic of nuclear reactors used for the production ⁹⁹Mo［R］. USA: Ball Systems Company, 1997.
［8］Maria L. Alternative production methods to face global molybdenum-99 supply shortage［J］. Hellenic Journal of Nuclear Medicine, 2011, 14(1): 49-55.
［9］李明起,邓启民. 医用放射性同位素生产现状和主要问题［J］. 同位素,2013,26(3):186-191.Li Mingqi, Deng Qimin. Production and application of medical radionuclide: status and urgent problems to be resolved in China［J］. Journal of Isotopes, 2013, 26(3):186-191(in Chinese).
［10］王刚,向学琴,傅红宇,等. 应用溶液堆生产裂变⁹⁹Mo［J］. 同位素,2004,17(4):247-249.Wang Gang, Xiang Xueqin, Fu Hongyu, et al. The production of fission ⁹⁹Mo using a solution reactor［J］. Journal of Isotopes, 2004, 17(4): 247-249(in Chinese).
［11］Sameh A A, Ache H J. Production techniques of fission ⁹⁹Mo［M］∥IAEA. IAEA-TECDOC-515. Karlsruhe: ［s.n.］, 1987: 13-16.
［12］Khvostionov V Y E, Pavshook V A, Talyzin V M. Studies of the opportunity to convert the ARGUS-90 research reactor with 90% fuel enrichment in U-235 to low enriched fuel (20%): RERTR Conference［C］. Wyoming: Argonne National Lab, 1997: 5-10.
［13］邓启民,李茂良,程作用. 利用医用同位素生产堆生产⁸⁹Sr［J］. 同位素,2007,20(3):185-188.Deng Qimin, Li Maoliang, Cheng Zuoyong. Strontium-99 production through medical isotope production reactor(MIPR)［J］. Journal of Isotopes, 2007, 20(3): 185-188(in Chinese).

[1]	薛岳, 徐广铎. 中国核技术应用产业发展现状[J]. 同位素, 2021, 34(2): 97-103.
[2]	宋志浩, 张蕴瀚, 王宁, 郭宏利, 赵海龙, 高翔. 使用活性炭纤维从中性钼溶液中提取锝的方法研究[J]. 同位素, 2021, 34(2): 133-140.
[3]	龚杰, 何明, 赵庆章, 庞义俊, 胡畔, 张文慧, 张宇轩, 武绍勇. Pu同位素的AMS测量方法研究进展[J]. 同位素, 2021, 34(2): 181-188.
[4]	王洁茹;陈德胜;黄清钢;秦芝;郭治军;吴晓蕾;初剑;白静;田伟;范芳丽;殷小杰;谈存敏;曹石巍. 质子引起天然铀裂变产生医用同位素钼-99的研究[J]. 同位素, 2020, 33(6): 347-355.
[5]	邓启民;程作用. 医用同位素生产堆燃料溶液杂质元素分离研究[J]. 同位素, 2020, 33(6): 361-365.
[6]	李波;罗宁;曾俊杰;吴建荣;贾致军;王磊;孙志中;陈云明;张劲松. ¹²⁵I生产工艺研究进展与展望[J]. 同位素, 2020, 33(6): 366-373.
[7]	胡畔;何明;赵庆章;庞义俊;龚杰;包轶文;游曲波;李康宁;苏胜勇;胡跃明. ¹²⁹I的小型化AMS测量技术研究[J]. 同位素, 2020, 33(4): 199-206.
[8]	于波;赵庆章;何明;庞义俊;张宇轩;胡畔;王芳芳;武绍勇;姜山. 一种新型气体探测器的研制[J]. 同位素, 2020, 33(2): 95-101.
[9]	王风;朱华;李立强;郭晓轶;刘特立;杨志. 新型固体靶核素⁸⁹Zr的制备、标记和临床前应用研究进展[J]. 同位素, 2020, 33(2): 117-123.
[10]	张宇轩;赵庆章;何明;王芳芳;庞义俊;于波;武绍勇;姜山;董克君. 加速器质谱测量⁶⁰Fe方法的模拟研究[J]. 同位素, 2019, 32(5): 343-348.
[11]	王芳芳;何明;张宇轩;赵庆章;王小明;庞义俊;武绍勇;孟齐;姜山. 加速器质谱测量⁶⁰Fe的样品制备与引出方法[J]. 同位素, 2019, 32(2): 103-107.
[12]	赵禹;刘向红;张玉龙;李海颖. 医用同位素生产堆应急停堆系统设计研究[J]. 同位素, 2019, 32(2): 128-132.
[13]	罗宁;曾俊杰;陈云明;孙志中;张劲松;梁帮宏;胡银;李兵;钟军;王小兵. 利用HFETR制备高比活度锶-89溶液[J]. 同位素, 2019, 32(1): 7-12.
[14]	徐超;洪冰;彭海军;丁寒维;洪业汤;朱詠煊. 加速器质谱¹⁴C样品制备中Zn-TiH₂法石墨产率探讨[J]. 同位素, 2018, 31(4): 248-255.
[15]	罗志福;吴宇轩;梁积新. 用于医用核素钼-99的制备方法[J]. 同位素, 2018, 31(3): 129-142.