国产FDG模块半自动合成18F-氟乙基胆碱

doi:10.7538/tws.2016.29.01.0019

摘要/Abstract

摘要：

¹⁸F-氟乙基胆碱（¹⁸F-FECH）是¹⁸F-FDG的重要补充，在脑瘤转移和前列腺癌及转移的诊断方面有重要的应用价值。利用国产单次PET-FDG-TI-I CPCU型FDG合成模块，未改变硬件，通过更改试剂与耗材，半自动合成¹⁸F-FECH，并在产品收集瓶前增加C18纯化柱，减少K_2.2.2杂质的含量。合成时间约30 min，放化产率42.0% （未时间校正，n=5），放置6 h后放化纯度>99.0%，体外稳定性良好；合成时间和产率与国内外模块结果相近。结果表明，在国产单次PET-FDG-TI-I CPCU型FDG模块上可半自动合成¹⁸F-FECH，合成效率及放化纯度较高。

关键词: ¹⁸F-氟乙基胆碱(¹⁸F-FECH), PET, 显像剂

Abstract:

As an important complementary imaging agent for ¹⁸F-FDG, ¹⁸F-fluoroethyl-choline (¹⁸F-FECH) has been demonstrated to be promising in brain and prostate cancer imaging. By using domestic PET-FDG-TI-I CPCU synthesizer, ¹⁸F-FECH was synthesized by different reagents and consumable supplies. The C18 column was added before the product collection bottle to remove K_2.2.2. The ¹⁸F-FECH was synthesized by PET-FDG-IT-I synthesizer efficiently about 30 minutes by radiochemical yield of 42.0% (no decay corrected, n=5), and the radiochemical purity was still more than 99.0% after 6 hours. The results showed the domestic PET-FDG-IT-I synthesizer could semi-automatically synthesize injectable ¹⁸F-FECH in high efficiency and radiochemical purity.

Key words: ¹⁸F-fluoroethyl-choline (¹⁸F-FECH), PET, imaging agent

周明;张晓军;刘健;李云钢;张锦明. 国产FDG模块半自动合成¹⁸F-氟乙基胆碱[J]. 同位素, 2016, 29(1): 19-24.

ZHOU Ming;ZHANG Xiao-jun;LIU Jian;LI Yun-gang;ZHANG Jin-ming. The Semi-automatic Synthesis of ¹⁸F-fluoroethyl-choline by Domestic FDG Synthesizer[J]. Journal of Isotopes, 2016, 29(1): 19-24.

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国产FDG模块半自动合成¹⁸F-氟乙基胆碱

The Semi-automatic Synthesis of ¹⁸F-fluoroethyl-choline by Domestic FDG Synthesizer

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