同位素 ›› 2015, Vol. 28 ›› Issue (4): 214-224.DOI: 10.7538/tws.2015.28.04.0214

• 综述 • 上一篇    下一篇

肿瘤氨基酸代谢PET显像研究进展

聂大红1;唐刚华2   

  1. 1.中山大学附属第一医院 放疗科, 广东 广州510080;2.中山大学附属第一医院 核医学科, 广东 广州510080
  • 出版日期:2015-11-20 发布日期:2015-12-07

Research Progress of Amino Acid Metabolism PET Imaging in Tumor

NIE Da-hong1;TANG Gang-hua2   

  1. 1.PET-CT Center, The First Affiliated Hospital, Sun Yat-Sen University, Gaungzhou 510080, China;2.Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China
  • Online:2015-11-20 Published:2015-12-07

摘要:

氨基酸代谢PET显像在代谢分子显像中占有重要的地位。氨基酸PET药物可分为[1-11C]氨基酸、标记α-碳位氨基酸、标记侧链氨基酸和N-取代标记氨基酸,肿瘤细胞摄取氨基酸PET药物机理主要涉及氨基酸转运。氨基酸代谢PET显像在神经精神疾病、脑瘤、神经内分泌肿瘤,以及其他多种肿瘤鉴别诊断方面具有优势。本文主要对肿瘤氨基酸代谢PET显像的研究进展进行了综述。

关键词: 肿瘤, 氨基酸转运, 氨基酸代谢, PET显像

Abstract:

Amino acid metabolism PET imaging plays a very important role in metabolism molecular imaging. Amino acid PET tracers include [1-11C]amino acid, labeling α-C amino acid, labeling side-chain amino acid, and N-substituted labeling amino acid. Uptake mechanism of these amino acids in tumor mainly involves in amino acid transport and amino acid metabolism PET imaging has an advantage of differential diagnosis of neuropsychiatric diseases, brain cancer, neuroendocrine tumor, and other tumors. The research progress of amino acid metabolism PET imaging in tumor were summarized.

Key words: tumor, amino acid transport, amino acid metabolism, PET imaging