同位素 ›› 2015, Vol. 28 ›› Issue (4): 201-206.DOI: 10.7538/tws.2015.28.04.0201

• 综述 • 上一篇    下一篇

同位素示踪RRL肿瘤新生血管显像的应用

王荣福   

  1. 北京大学 第一医院,北京100034
  • 出版日期:2015-11-20 发布日期:2015-12-07

Application Study on Isotope Tracing RRL Tumor Angiogenesis Imaging

WANG Rong-fu   

  1. Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China
  • Online:2015-11-20 Published:2015-12-07

摘要:

肿瘤血管生成在肿瘤的生长、侵犯以及转移过程发挥着重要的作用。新型肿瘤血管示踪剂RRL可以靶向结合于肿瘤血管内皮细胞上的VEGFR-2受体,示踪不同类型和不同侵袭力恶性肿瘤组织的新生血管,为恶性肿瘤的诊断、治疗及预后评估提供有效信息。本文对靶向肿瘤新生血管多肽RRL在核素示踪领域的应用及新进展进行了综述。

关键词: 肿瘤, 新生血管, 同位素, 分子探针, 显像

Abstract:

Angiogenesis plays crucial roles in the progress of tumor growth, progression and metastases. The new tumor blood vessel tracer RRL can be targeted to the VEGFR-2 receptor on tumor vascular endothelial cells, Tracing with radioisotopes different types of tumor and angiogenesis in malignant tumor tissues with different invasive ability will provide the important information on the diagnosis, treatment and evaluated prognosis of malignant tumor. In this review, the recent study and progresses on molecular imaging with the peptide RRL in tumor angiogenesis will be summarized.

Key words: tumor, angiogenesis, isotope, molecular probe, imaging