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• 放射性药物和标记化合物 • 上一篇    下一篇

氯胺酮依赖脑内作用靶点的可视化研究

杨红杰1,2;胡疏1;贾少微1;高宙1;王彤3;赵正勤1   

  1. 1. 北京大学 深圳医院,广东 深圳518036;2. 北京大学 医学部,北京100191;3. 清华大学 深圳研究生院,广东 深圳518055
  • 出版日期:2014-05-20 发布日期:2014-06-09

Molecular Imaging on the Cerebral Pathological Damage Target of Ketamine Dependence

YANG Hong-jie1,2;HU Shu1;JIA Shao-wei1;GAO Zhou1;WANG Tong3;ZHAO Zheng-qin1   

  1. 1. Peking University Shenzhen Hospital, Shenzhen 518036, China;2. Peking University Health Science Center, Beijing 100191, China 3. Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
  • Online:2014-05-20 Published:2014-06-09

摘要:

应用SPECT分子影像技术在生理状态下可视化研究氯胺酮依赖的脑内损害靶点。随机选择20例来北京大学深圳医院门诊就诊的氯胺酮依赖患者,随机有偿招募的31例健康志愿者为对照组,分别对其行SPECT DAT显像。由专业医师对上述患者的显像结果进行定性及定量分析,计算氯胺酮依赖患者和健康志愿者纹状体的体积、质量和纹状体与全脑放射性比值(Ra)。所得结果采用SPSS 16.0软件进行t检验分析。健康志愿者对照组双侧纹状体外形饱满、等大,放射性分布均匀对称,呈“熊猫眼”形态;氯胺酮依赖组双侧纹状体明显变小,外形呈多种形态改变,双侧纹状体DAT的分布、结合位点、数量和活性下降;同时脑内放射性分布紊乱,非特异摄取明显增多。双侧纹状体体积为(21.03±3.15) cm3、质量为(22.08±3.31) g、Ra=(5.37±1.08)%,均低于健康对照组(p<0.01)。氯胺酮依赖的脑内损害靶点与复方磷酸可待因止咳水、海洛因及摇头丸依赖类似,使脑内纹状体区DAT的功能受损。结果表明,脑内纹状体区域DAT为精神活性物质滥用作用的主要靶点。

关键词: 氯胺酮依赖, 单光子发射型计算机断层显像仪(SPECT), 多巴胺转运体, 99Tcm-TRODAT-1

Abstract:

To study the cerebral pathological damage target which result from abusing ketamine through molecular imaging techniques, 20 cases of ketamine dependent patients looking for treatment at the Peking University Shenzhen Hospital and 31 healthy volunteers were included in this study, all of them got brain SPECT DAT imaging. The results were analyzed by SPSS 16.0. The bilateral caudate nucleus and putamen of healthy volunteers were roughly equally large, and the radioactive distribution of DAT in healthy volunteers were uniform and symmetrical. The bilateral corpora striatum showed typical “panda eyes” pattern. But the bilateral corpora striatum of ketamine dependent patients got smaller in shape, got disorders in pattern, and the radioactive distribution of DAT reduced or defected or even got disturbance and with much more non-specific radioactive. The V, m and Ra of bilateral corpora striatum in ketamine dependent patients were (21.03±3.15) cm3, (22.08±3.31) g and (5.37±1.08) %, respectively, which were significantly lower than the healthy volunteers (p<0.01). The cerebral pathological damage target which resulted from abusing ketamine was similar to those of compound codeine phosphate antitussive solution dependence, heroin dependence and MDMA dependence, all of these psychoactive substances damaged the function of DAT.

Key words: ketamine, dependence, single photon emission computed tomography (SPECT), dopamine transport(DAT), 99Tcm-TRODAT-1