11C-乙酸盐自动化合成改进工艺及PET/CT显像

doi:10.7538/tws.2013.26.02.0073

同位素 ›› 2013, Vol. 26 ›› Issue (2): 73-78.DOI: 10.7538/tws.2013.26.02.0073

• 放射性药物和标记化合物及其应用 • 上一篇下一篇

¹¹C-乙酸盐自动化合成改进工艺及PET/CT显像

甘满权¹;唐小兰²;唐刚华³;王红亮³;胡孔珍³

1.广州医学院第一附属医院 PET/CT中心，广州510230;2.华南农业大学理学院，广州510642; 3.中山大学附属第一医院核医学科，广州510515

出版日期:2013-05-20 发布日期:2013-06-18

Improved AutomatedSynthesis and Preliminary Animal PET/CT Imaging of ¹¹C-acetate

GAN Man-quan¹;TANG Xiao-lan²;TANG Gang-hua³;WANG Hong-liang³;HU Kong-zhen³

1.PET/CT Center, The FirstAffiliated Hospital of Guangzhou MedicalCollege, Guangzhou 510230，China；2.College of Science, Southern China AgriculturalUniversity, Guangzhou 510642，China；3.Department of NuclearMedicine, The First Affiliated Hospital,Sun Yat-Sen University, Guangzhou 510515， China

Online:2013-05-20 Published:2013-06-18

摘要/Abstract

摘要：

采用国产碳-11胆碱/蛋氨酸自动合成模块，研究简单、快速、自动化合成¹¹C乙酸盐(¹¹C-AC)的工艺流程。¹¹C-CO₂与溴化甲基镁(MeMgBr)在改进的Loop环内反应生成中间体乙酰溴化镁加合物，中间体经在柱水解和SEP-PAK小柱纯化后制备¹¹C-AC 注射液。总合成时间约8min，校正放化产率为(40.5±4.6)%，放化纯度大于95%。该改进法适于多种商用全自动化模块自动化生产¹¹C-AC。生产的¹¹C-AC注射液安全、有效，有望用于动物和人体PET显像研究。

关键词: ^{font-family: 'Times New Roman'">11}font-family: 'Times New Roman'">Cfont-family: 'Times New Roman'">-font-family: 宋体">乙酸盐font-family: 'Times New Roman'">, PETfont-family: 宋体">显像剂font-family: 'Times New Roman'">, font-family: 宋体">自动化合成

Abstract:

To study a simple and rapidautomated synthetic technology of ¹¹C-acetate(¹¹C-AC), automatedsynthesis of ¹¹C-ACwas performed by carboxylation of MeMgBr/tetrahydrofuran (THF) on apolyethylene loop with ¹¹C-CO₂,followed by hydrolysis and purification on solid-phase extraction cartridgesusing a ¹¹C-Choline/Methioninesynthesizer made in China. A high and reproducible radiochemical yield of above40% (decay corrected) was obtained within the whole synthesis time about 8 minfrom ¹¹C-CO₂.The radiochemical purity of ¹¹C-ACwas over 95%. The novel, simple and rapid on-column hydrolysis-purificationprocedure should adaptable to the fully automated synthesis of ¹¹C-AC at several commercialsynthesis module. ¹¹C-ACinjection produced by the automated procedure is safe and effective, and can beused for PET imaging of animals and humans.

Key words: ^{font-family: 'Times New Roman'">11}font-family: 'Times New Roman'">Cfont-family: 'Times New Roman'">-acetate, PET imaging agent, automated synthesis

甘满权;唐小兰;唐刚华;王红亮;胡孔珍. ¹¹C-乙酸盐自动化合成改进工艺及PET/CT显像[J]. 同位素, 2013, 26(2): 73-78.

GAN Man-quan;TANG Xiao-lan;TANG Gang-hua;WANG Hong-liang;HU Kong-zhen. Improved AutomatedSynthesis and Preliminary Animal PET/CT Imaging of ¹¹C-acetate[J]. Journal of Isotopes, 2013, 26(2): 73-78.

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¹¹C-乙酸盐自动化合成改进工艺及PET/CT显像

Improved AutomatedSynthesis and Preliminary Animal PET/CT Imaging of ¹¹C-acetate

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