SPECT脑血流灌注显像的临床应用价值及对缺血性脑血管病支架植入术后的疗效评价

doi:10.7538/tws.2010.23.04.0242

同位素 ›› 2010, Vol. 23 ›› Issue (4): 242-246.DOI: 10.7538/tws.2010.23.04.0242

• 放射性同位素应用技术 • 上一篇下一篇

SPECT脑血流灌注显像的临床应用价值及对缺血性脑血管病支架植入术后的疗效评价

赵鹏;高沁怡;尹雅芙;李亚明

中国医科大学附属第一医院核医学科，辽宁沈阳110001

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-11-20 发布日期:2010-11-20

Therapeutic Evaluation of Intravascular Stenting in Ischemic Cerebral Vascular Diseases and Clinical Application by SPECT Perfusion Imaging

ZHAO Peng;GAO Qin-yi;YIN Ya-fu;LI Ya-ming

Department of Nuclear Medicine,the First Clinical Hospital of China Medical University, Shenyang 110001, China

Received:1900-01-01 Revised:1900-01-01 Online:2010-11-20 Published:2010-11-20

摘要/Abstract

摘要： 采用SPECT脑血流灌注显像法对缺血性脑血管病支架植入术患者术后的疗效进行了评价。27例患者经数字减影血管造影(Digital Subtraction Angiography,DSA)证实存在脑血管狭窄，并行脑CT、MR及⁹⁹Tc^m-ECD SPECT检查。10例患者施行狭窄处支架成形术，其中7例患者于术后3～6个月复查SPECT脑血流灌注显像，通过半定量分析法对比手术前后缺血灶感兴趣区局部脑血流量(rCBF)与小脑rCBF比值的改变，评价术后局部脑血流改善状况。结果显示，SPECT脑血流灌注显像较MR、CT显像能显示出更多的缺血区域，但基底节和室旁白质除外；7例进行介入治疗手术的患者，其术前SPECT反映17处缺血区与同侧小脑rCBF比均数为73.42%，术后为80.67%，较术前有显著改善，P<0.01。以上结果提示，⁹⁹Tc^m-ECD SPECT脑血流灌注显像对脑缺血病灶反映较为敏感，并能很好地评价施行支架植入术后患者的脑血流状况。

关键词: ⁹⁹Tc^m-ECD, SPECT, 脑血流灌注显像, 缺血性脑血管病, 疗效评价

Abstract: Application value of SPECT perfusion imaging and its therapeutic evaluation after intravascular stenting in ischemic cerebral vascular diseases were sudied. 27 patients with cerebral vessels stenosis were confirmed by digital subtraction angiography (DSA) and checked by CT，MR and ⁹⁹Tc^m-ECD SPECT perfusion imaging. 10 of them underwent angioplasty in site of stenosis , SPECT perfusion imaging was used in 7 of the 10 cases after 3-6 months of operation, ratio of rCBF in ischemic area to the same side cerebellum were determined by means of semi-quantitative analyses, and improvement of the regional cerebral blood flow after operation was evaluated. Numbers of ischemic regions were founded by SPECT perfusion imaging more than that founded by CT or MR, but except the basal ganglia and the periventricular white matter. The mean ratio of 17 ischemic regions before operation was 73.42% , in comparison with 80.67% after operation in 7 operated patients(P<0.01), that showed the blood flow improved obviously.⁹⁹Tc^m-ECD SPECT perfusion imaging may reflect sensitively to the ischemic foci and may evaluate perfectly the condition of regional cerebral blood flow after intravascular stenting.

Key words: ⁹⁹Tc^m-ECD, SPECT, perfusion imaging, ischemic cerebral vascular disease, therapeutic evaluation

赵鹏;高沁怡;尹雅芙;李亚明. SPECT脑血流灌注显像的临床应用价值及对缺血性脑血管病支架植入术后的疗效评价[J]. 同位素, 2010, 23(4): 242-246.

ZHAO Peng;GAO Qin-yi;YIN Ya-fu;LI Ya-ming. Therapeutic Evaluation of Intravascular Stenting in Ischemic Cerebral Vascular Diseases and Clinical Application by SPECT Perfusion Imaging[J]. Journal of Isotopes, 2010, 23(4): 242-246.

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SPECT脑血流灌注显像的临床应用价值及对缺血性脑血管病支架植入术后的疗效评价

Therapeutic Evaluation of Intravascular Stenting in Ischemic Cerebral Vascular Diseases and Clinical Application by SPECT Perfusion Imaging

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