自制美沙西汀-甲氧基-13C的表征

doi:10.7538/tws.2010.23.04.0216

同位素 ›› 2010, Vol. 23 ›› Issue (4): 216-220.DOI: 10.7538/tws.2010.23.04.0216

• 特约专栏：稳定同位素制备及应用技术 • 上一篇下一篇

自制美沙西汀-甲氧基-¹³C的表征

卢伟京¹;卢浩¹;杨维成¹;管樑²;朱承谟²;刘卫霞¹;李帅¹;徐仲杰¹;陈素芸²;姜磊²

1.上海化工研究院，上海200062；2.上海交通大学医学院附属瑞金医院核医学科，上海200025

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-11-20 发布日期:2010-11-20

Characterization of Methacetin-methoxy-¹³C

LU Wei-jing¹;LU Hao¹;YANG Wei-cheng¹;GUAN Liang²;ZHU Cheng-mo²;LIU Wei-xia¹;LI Shuai¹;XU Zhong-jie¹;CHEN Su-yun²;JIANG Lei²

1. Shanghai Research Institute of Chemical Industry, Shanghai 200062, China；2. Department of Nuclear Medicine, Ruijing Hospital, Shanghai Jiao Tong University, Shanghai 200025, China

Received:1900-01-01 Revised:1900-01-01 Online:2010-11-20 Published:2010-11-20

摘要/Abstract

摘要： 采用新的方法，以甲醇-¹³C为原料直接合成了美沙西汀-甲氧基-¹³C，并对其进行了HPLC、LC-MS和¹HMNR等分析。结果表明，所合成的样品是目标产品，产率为70.0%，¹³C丰度为99%，纯度为99.8%。与经典的合成方法比较，本方法具有较好的经济效益。使用本方法自制的美沙西汀-甲氧基-¹³C进行小鼠¹³C-呼吸试验，结果表明，美沙西汀-甲氧基-¹³C可以在小鼠活体状态下正确评估其损伤和恢复情况。

关键词: 美沙西汀-甲氧基-¹³C, ¹³C-呼吸实验, 表征

Abstract: Methacetin-methoxy-¹³C was synthesized by using methanol-¹³C with a novel method, and the characterization of it was performed using HPLC, LC-MS and ¹HMNR. The results indicated that the synthetic was right. And the yield of methacetin-methoxy-¹³C was 70.0% with 99% ¹³C abundance and 99.8% purity. Compared with the classical method， there was more benefit. The methacetin ¹³C-breath test was performed with the synthetic on the live mice, which showed a precise reflection of alteration of liver function in liver injury and functional recovery.

Key words: methacetin-methoxy-¹³C, ¹³C-breath test, characterization

卢伟京 ;卢浩 ;杨维成 ;管樑 ;朱承谟 ;刘卫霞 ;李帅 ;徐仲杰 ;陈素芸 ;姜磊 . 自制美沙西汀-甲氧基-¹³C的表征[J]. 同位素, 2010, 23(4): 216-220.

LU Wei-jing;LU Hao;YANG Wei-cheng;GUAN Liang;ZHU Cheng-mo;LIU Wei-xia;LI Shuai;XU Zhong-jie;CHEN Su-yun;JIANG Lei. Characterization of Methacetin-methoxy-¹³C[J]. Journal of Isotopes, 2010, 23(4): 216-220.

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自制美沙西汀-甲氧基-¹³C的表征

Characterization of Methacetin-methoxy-¹³C

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