177Lu-EDTMP放化纯度分析方法的建立

doi:10.7538/tws.2010.23.03.0163

同位素 ›› 2010, Vol. 23 ›› Issue (3): 163-165.DOI: 10.7538/tws.2010.23.03.0163

• 放射性药物和标记化合物 • 上一篇下一篇

¹⁷⁷Lu-EDTMP放化纯度分析方法的建立

柳银黎;尹光荣;付博;叶肇云;王晓静

原子高科股份有限公司，北京102413

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-08-20 发布日期:2010-08-20

Establishment of Analysis Method for the Radiochemical Purity of ¹⁷⁷Lu-EDTMP

LIU Yin-li;YIN Guang-rong;FU Bo;YE Zhao-yun;WANG Xiao-jing

Atom High Tech Co. Ltd., Beijing 102413, China

Received:1900-01-01 Revised:1900-01-01 Online:2010-08-20 Published:2010-08-20

摘要/Abstract

摘要： 建立了¹⁷⁷Lu-EDTMP放化纯度的纸色谱分析方法。以V(水)∶V(氨水)=50∶2为展开剂，Whatman No.540为固定相，在碱性条件下对¹⁷⁷Lu-EDTMP和杂质¹⁷⁷Lu³⁺进行分离。分析结果显示，本方法的分离度较好，¹⁷⁷Lu³⁺的R_f=0，¹⁷⁷Lu-EDTMP的R_f=0.9～1.0；方法相对标准偏差＜1%。本方法简便、快速，适用于¹⁷⁷Lu-EDTMP溶液及药盒的放化纯度分析。

关键词: ¹⁷⁷Lu-EDTMP, 放化纯度, 分析方法

Abstract: The paper chromatography method for determination of ¹⁷⁷Lu-EDTMP radiochemical purity was established. ¹⁷⁷Lu-EDTMP was separated from impurities ¹⁷⁷Lu³⁺ under alkaline conditions with V(water)∶V(ammonia)=50∶2 solution as developing reagent and Whatman No.540 as stationary phase. There was a better separation using this method, the R_f of ¹⁷⁷Lu³⁺and ¹⁷⁷Lu-EDTMP were 0 and 0.9～1.0 respectively. The relative standard deviation was less than 1%. This method was simpler, quicker and suitable for the analysis of radiochemical purity of solution and kit composed of ¹⁷⁷Lu-EDTMP.

Key words: ¹⁷⁷Lu-EDTMP, radiochemical purity, analytical method

柳银黎;尹光荣;付博;叶肇云;王晓静. ¹⁷⁷Lu-EDTMP放化纯度分析方法的建立[J]. 同位素, 2010, 23(3): 163-165.

LIU Yin-li;YIN Guang-rong;FU Bo;YE Zhao-yun;WANG Xiao-jing. Establishment of Analysis Method for the Radiochemical Purity of ¹⁷⁷Lu-EDTMP[J]. Journal of Isotopes, 2010, 23(3): 163-165.

[1]	王吉欣;张艳华. 薄层色谱“一条”法检测⁹⁹Tc^m药物的放化纯度[J]. 同位素, 2010, 23(3): 170-172.
[2]	刘佳宁;刘一兵;贾娟娟;许文革;张雪峰;韩世泉. 促黄体生成激素酶促化学发光免疫分析方法的建立[J]. 同位素, 2010, 23(1): 28-33.
[3]	作者. ~(18)FDG注射液放化纯度的测定[J]. 同位素, 2004, 17 (2 ): 104-104 .
[4]	作者. ~(18)FDG注射液放化纯度的测定[J]. 同位素, 2004, 17 (2 ): 104-104 .
[5]	作者. 肿瘤受体显像剂~(99)Tc~m-octreotide的放化纯度分析 [J]. 同位素, 2003, 16(1 ): 26-26 .
[6]	作者. HPLC法分析~(18)F-FDG放化纯度 [J]. 同位素, 2001, 14(Z1 ): 214-214 .
[7]	作者. ~(129)I分析方法进展 [J]. 同位素, 2000, 13 (1 ): 28-28 .
[8]	作者. 心肌显像剂~(99)Tc~mN(NOEt)_2放化纯度的分析 [J]. 同位素, 2000, 13 (1 ): 25-25 .
[9]	作者. 关于放射性药物放射化学纯度测定的探讨 [J]. 同位素, 1998, 11 (2 ): 50-57+5.
[10]	作者. ~(99)Tc~m右旋糖酐中~(99)Tc~mO_2胶体测定方法的探讨 [J]. 同位素, 1995, 8 (3 ): 167-171 .

¹⁷⁷Lu-EDTMP放化纯度分析方法的建立

Establishment of Analysis Method for the Radiochemical Purity of ¹⁷⁷Lu-EDTMP

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 10

编辑推荐

Metrics