Abstract：The determination of pertechnetate in techetium[99Tc] methylenediphosphonate injection by HPLC is proposed .The effects of analytical column ,eluent and detection wavelenegth are studied . The detection conditions are on a XTerra RP18 column ,using 0.03mol/L HAc-NaAc as mobile phase with a flow rate of 1.0 mL/min and detection wavelenegth of 248nm .The retention time of 99TcO4- is 2.2min and detection limit of 99Tc is 110-3μg .The range of the recovery is 90%～97%，and relative standard diversion is less than 2%.
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