同位素 ›› 2008, Vol. 21 ›› Issue (3): 165-169.DOI: 10.7538/tws.2008.21.03.0165
• 研究简报 • 上一篇 下一篇
叶肇云；赵秀岩；姜 华；赵 岩
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摘要： 建立了测定锝[99Tc]亚甲基二膦酸盐注射液A剂中99TcO4-含量的高效液相色谱法。对色谱柱、流动相和检测波长等实验条件进行了选择，确定采用XTerra RP18色谱柱，0.03mol/L HAc-NaAc（pH5.5）缓冲溶液为流动相，流速1.0mL/min，检测波长248nm，保留时间2.2min，检测下限1X10-3μg（以99Tc计），方法的回收率90%～97%，精密度<2%。
关键词: 高效液相色谱法, 高锝[99Tc]酸盐, 测定
Abstract: The determination of pertechnetate in techetium[99Tc] methylenediphosphonate injection by HPLC is proposed .The effects of analytical column ,eluent and detection wavelenegth are studied . The detection conditions are on a XTerra RP18 column ,using 0.03mol/L HAc-NaAc as mobile phase with a flow rate of 1.0 mL/min and detection wavelenegth of 248nm .The retention time of 99TcO4- is 2.2min and detection limit of 99Tc is 110-3μg .The range of the recovery is 90%～97%，and relative standard diversion is less than 2%.
Key words: high performance liquid chromatography, pertechnetate, determination
叶肇云;赵秀岩;姜 华;赵 岩. HPLC法测定99Tc—亚甲基二膦酸盐注射液A剂中高锝酸盐含量[J]. 同位素, 2008, 21(3): 165-169.
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链接本文: http://www.tws.org.cn/CN/10.7538/tws.2008.21.03.0165
http://www.tws.org.cn/CN/Y2008/V21/I3/165
