同位素 ›› 2007, Vol. 20 ›› Issue (1): 33-36.DOI: 10.7538/tws.2007.20.01.0033

• 研究简报 • 上一篇    下一篇

188Re-DTPA-DG的制备及其在荷瘤裸 鼠体内的分布

陈跃   

  1. 四川省泸州医学院附属医院核医学科
  • 收稿日期:2006-12-18 修回日期:2006-12-26 出版日期:2007-02-20 发布日期:2007-02-20
  • 通讯作者: 陈跃

Preparation and Biodistribution of 188Re-DTPA-DG in Mice Bearing MCF-7

CHEN Yue 陈跃   

  • Received:2006-12-18 Revised:2006-12-26 Online:2007-02-20 Published:2007-02-20
  • Contact: CHEN Yue 陈跃

摘要: 制备了188Re-DTPA-DG并对其在荷瘤裸鼠的体内分布进行了初步探讨。将葡胺盐酸盐与DTPA连接,合成DTPA-DG,再用188Re标记,并进行荷MCF-7乳腺癌裸鼠的体内分布特性研究。结果表明,188Re-DTPA-DG的标记率95.0%。静脉注射188Re-DTPA-DG后12 h,肿瘤与周围肌肉的含量比值高达12.76:1。188Re-DTPA-DG显示较好肿瘤靶向性。

关键词: 188Re-DTPA-DG,, MCF-7乳腺癌, 体内分布

Abstract: The purpose of this article is to study the preparation and biodistribution of 188Re-DTPA-DG in nude mice bearing MCF-7 mammary cancer cell. DTPA-deoxyglucose (DTPA-DG) was synthesized by conjugating D-glucosamine to diethylenetriaminepentaacetic acid (DTPA), then radiolabeled with 188Re. The biodistribution of 88Re-DTPA-DG in nude mice bearing MCF-7 mammary cancer cell was studied. The result showed that the radiolabeling yield of 188Re-DTPA-DG was 95.0%. The tumor-to-muscle ratio at 12h post intravenous injection was 12.76. 188Re-DTPA-DG showed excellent tumor targeting.

Key words: 188Re-DTPA-DG, MCF-7 mammary cancer, Biodistribution