同位素 ›› 2006, Vol. 19 ›› Issue (3): 135-140.DOI: 10.7538/tws.2006.19.03.0135

• 论文 • 上一篇    下一篇

长链脂肪酸衍生物99Tcm-MAMA-(CH2)nCOOH的制备和生物分布

吴战宏;王学斌   

  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-05-20 发布日期:2006-05-20
  • 通讯作者: 王学斌

Preparation and Biodistribution of Long-chain Fatty Acid Analogues:99Tcm-MAMA-FA

  • Received:1900-01-01 Revised:1900-01-01 Online:2006-05-20 Published:2006-05-20

摘要: 以短链二酸和N2S2类配体(MAMA)为起始原料,合成了4个长链脂肪酸衍生物MAMA-(CH2)nCOOH(n=14,15,16,17),通过与99Tcm-GH在沸水浴中加热30 min完成配体交换反应,实现了99Tcm的标记,其标记率均大于90%。正常小鼠的生物分布数据显示这4个标记物在心肌中均有一定的摄取(5 min时的放射性摄取百分数依次为5.73、5.52、4.82和4.03%ID•g-1),但血本底较高,而且血清除较慢,标记物能否参与脂肪酸尚需进一步研究。

关键词: 99Tcm-MAMA-FA, 脂肪酸代谢显像剂, 长链脂肪酸

Abstract: Four long-chain fatty acid analogues MAMA-(CH2)nCOOH (n=14,15,16,17) are synthesized from medium-chain fatty acid and monoamine-monoamide dithiol ligand (MAMA). 99Tcm complexes (99Tcm-MAMA-FA) are prepared by ligand-exchange reaction with 99Tcm-GH in boiling water bath for the development of 99Tcm labeled fatty acid metabolism imaging agent ,and their biodistributions in normal mice are studied. The results indicate that the four labeled compounds have low initial heart uptake,but they have high blood uptake and slow blood clearance.

Key words: 99Tcm-MAMA-FA, myocardialmetabolicagent, lang-chainfattyacid, preparation