同位素 ›› 2003, Vol. 16 ›› Issue (Z1 ): 197-197 .DOI: 10.7538/tws.2003.16.Z1.0197

• 论文 • 上一篇    下一篇

氘氚标记治疗老年性痴呆症药物zt-1

作者   

  1. @吴元芳$中国科学院上海应用物理研究所!上海201800 @李惠源$中国科学院上海应用物理研究所!上海201800 @董墨$中国科学院上海应用物理研究所!上海201800
  • 收稿日期:2003-07-15 出版日期:2003-10-20 发布日期:2003-10-20

Preparation of Labelled zt-1 With Tritium and Deuterium

  1. WU Yuan-fang,LI Hui-yuan,DONG Mo (Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China)
  • Received:2003-07-15 Online:2003-10-20 Published:2003-10-20

摘要: 用钠硼氘、钠硼氚还原5-氯-邻香草醛制备氘标记、氘标记5-氯-邻香草醛,然后与石杉碱甲在避光条件 下缩合生成氘标记、氚标记zt-1。经硅胶板层析所得Rf与zt-1标准品的一致,经紫外检测其λmax=303nm也 与标准品的一致。氚标记zt-1的放化纯度>95%,放射性比活度为401.3GBq/g。

关键词: 氘标记zt-1, 氚标记zt-1, 治疗老年性痴呆药物zt-1

Abstract: zt-1 is a petential drug for treatment of Alzheimer's disease. For the study of this drug, isotope labeled compounds should be prepared. After reduction of 5-chloro-o-vanillin with sodium boron deuteride and triterid, and condensation, zt-1 labeled with tritium and deuterium are prepared. UV absorption spectrum and Rf of tritium labeled zt-1 are the same as authentic sample. The radiochemical purity of 3H-zt-l is more than 95%, and the specific radioactivity is 401. 3 GBq/g.

Key words: zt-1 labelled with deuterium, labelled with tritium, zt-1

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