同位素 ›› 2003, Vol. 16 ›› Issue (Z1 ): 197-197 .DOI: 10.7538/tws.2003.16.Z1.0197
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摘要: 用钠硼氘、钠硼氚还原5-氯-邻香草醛制备氘标记、氘标记5-氯-邻香草醛,然后与石杉碱甲在避光条件 下缩合生成氘标记、氚标记zt-1。经硅胶板层析所得Rf与zt-1标准品的一致,经紫外检测其λmax=303nm也 与标准品的一致。氚标记zt-1的放化纯度>95%,放射性比活度为401.3GBq/g。
关键词: 氘标记zt-1, 氚标记zt-1, 治疗老年性痴呆药物zt-1
Abstract: zt-1 is a petential drug for treatment of Alzheimer's disease. For the study of this drug, isotope labeled compounds should be prepared. After reduction of 5-chloro-o-vanillin with sodium boron deuteride and triterid, and condensation, zt-1 labeled with tritium and deuterium are prepared. UV absorption spectrum and Rf of tritium labeled zt-1 are the same as authentic sample. The radiochemical purity of 3H-zt-l is more than 95%, and the specific radioactivity is 401. 3 GBq/g.
Key words: zt-1 labelled with deuterium, labelled with tritium, zt-1
中图分类号:
TQ463.7
O613.2
作者. 氘氚标记治疗老年性痴呆症药物zt-1 [J]. 同位素, 2003, 16(Z1 ): 197-197 .
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链接本文: http://www.tws.org.cn/CN/10.7538/tws.2003.16.Z1.0197
http://www.tws.org.cn/CN/Y2003/V16/IZ1 /197